Next Article in Journal
Molecular Basis of Interactions between the Antibiotic Nitrofurantoin and Human Serum Albumin: A Mechanism for the Rapid Drug Blood Transportation
Previous Article in Journal
Insights on Metabolic Reprogramming and Its Therapeutic Potential in Acute Leukemia
Previous Article in Special Issue
The Role of the Gut Microbiota in the Gut–Brain Axis in Obesity: Mechanisms and Future Implications
Article

Lectin-Mediated Bacterial Modulation by the Intestinal Nematode Ascaris suum

1
Institute of Immunology, Freie Universität Berlin, 14163 Berlin, Germany
2
Institute for Immunology & Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine Hannover, 30559 Hannover, Germany
3
Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany
4
Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany
5
Institute of Microbiology and Epizootics, Freie Universität Berlin, 14163 Berlin, Germany
6
Institute of Virology, Freie Universität Berlin, 14163 Berlin, Germany
7
Department of Viral Transformation, Leibniz Institute for Experimental Virology (HPI), 20251 Hamburg, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Manuel Z Cabrera
Int. J. Mol. Sci. 2021, 22(16), 8739; https://doi.org/10.3390/ijms22168739
Received: 28 June 2021 / Revised: 5 August 2021 / Accepted: 11 August 2021 / Published: 14 August 2021
(This article belongs to the Special Issue Strategies Targeting Microbiota Modulation)
Ascariasis is a global health problem for humans and animals. Adult Ascaris nematodes are long-lived in the host intestine where they interact with host cells as well as members of the microbiota resulting in chronic infections. Nematode interactions with host cells and the microbial environment are prominently mediated by parasite-secreted proteins and peptides possessing immunomodulatory and antimicrobial activities. Previously, we discovered the C-type lectin protein AsCTL-42 in the secreted products of adult Ascaris worms. Here we tested recombinant AsCTL-42 for its ability to interact with bacterial and host cells. We found that AsCTL-42 lacks bactericidal activity but neutralized bacterial cells without killing them. Treatment of bacterial cells with AsCTL-42 reduced invasion of intestinal epithelial cells by Salmonella. Furthermore, AsCTL-42 interacted with host myeloid C-type lectin receptors. Thus, AsCTL-42 is a parasite protein involved in the triad relationship between Ascaris, host cells, and the microbiota. View Full-Text
Keywords: Ascaris; helminths; intestinal nematode; microbiota; lectin; Salmonella; glycan array; C-type lectin; C-type lectin receptor Ascaris; helminths; intestinal nematode; microbiota; lectin; Salmonella; glycan array; C-type lectin; C-type lectin receptor
Show Figures

Figure 1

MDPI and ACS Style

Midha, A.; Goyette-Desjardins, G.; Goerdeler, F.; Moscovitz, O.; Seeberger, P.H.; Tedin, K.; Bertzbach, L.D.; Lepenies, B.; Hartmann, S. Lectin-Mediated Bacterial Modulation by the Intestinal Nematode Ascaris suum. Int. J. Mol. Sci. 2021, 22, 8739. https://doi.org/10.3390/ijms22168739

AMA Style

Midha A, Goyette-Desjardins G, Goerdeler F, Moscovitz O, Seeberger PH, Tedin K, Bertzbach LD, Lepenies B, Hartmann S. Lectin-Mediated Bacterial Modulation by the Intestinal Nematode Ascaris suum. International Journal of Molecular Sciences. 2021; 22(16):8739. https://doi.org/10.3390/ijms22168739

Chicago/Turabian Style

Midha, Ankur, Guillaume Goyette-Desjardins, Felix Goerdeler, Oren Moscovitz, Peter H. Seeberger, Karsten Tedin, Luca D. Bertzbach, Bernd Lepenies, and Susanne Hartmann. 2021. "Lectin-Mediated Bacterial Modulation by the Intestinal Nematode Ascaris suum" International Journal of Molecular Sciences 22, no. 16: 8739. https://doi.org/10.3390/ijms22168739

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop