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Article

Quantitative Assessment of Point-of-Care 3D-Printed Patient-Specific Polyetheretherketone (PEEK) Cranial Implants

1
Clinic of Oral and Cranio-Maxillofacial Surgery, University Hospital Basel, CH-4031 Basel, Switzerland
2
Medical Additive Manufacturing Research Group (Swiss MAM), Department of Biomedical Engineering, University of Basel, CH-4123 Allschwil, Switzerland
3
Basel Institute for Clinical Epidemiology and Biostatistics, Department of Clinical Research, University Hospital Basel, CH-4031 Basel, Switzerland
4
Institute for Medical Engineering and Medical Informatics, University of Applied Sciences and Arts North-Western Switzerland, CH-4132 Muttenz, Switzerland
5
Hand Surgery, Cantonal Hospital Baselland, CH-4410 Liestal, Switzerland
6
Amsterdam UMC, Department of Biomedical Engineering and Physics, University of Amsterdam, Amsterdam Movement Sciences, NL-1105 Amsterdam, The Netherlands
*
Author to whom correspondence should be addressed.
These authors contributed equally and shared the last authorship.
Academic Editor: Silvia Panseri
Int. J. Mol. Sci. 2021, 22(16), 8521; https://doi.org/10.3390/ijms22168521
Received: 10 July 2021 / Revised: 26 July 2021 / Accepted: 5 August 2021 / Published: 7 August 2021
(This article belongs to the Special Issue 3D Printing and Biomaterials for Biological and Medical Application)
Recent advancements in medical imaging, virtual surgical planning (VSP), and three-dimensional (3D) printing have potentially changed how today’s craniomaxillofacial surgeons use patient information for customized treatments. Over the years, polyetheretherketone (PEEK) has emerged as the biomaterial of choice to reconstruct craniofacial defects. With advancements in additive manufacturing (AM) systems, prospects for the point-of-care (POC) 3D printing of PEEK patient-specific implants (PSIs) have emerged. Consequently, investigating the clinical reliability of POC-manufactured PEEK implants has become a necessary endeavor. Therefore, this paper aims to provide a quantitative assessment of POC-manufactured, 3D-printed PEEK PSIs for cranial reconstruction through characterization of the geometrical, morphological, and biomechanical aspects of the in-hospital 3D-printed PEEK cranial implants. The study results revealed that the printed customized cranial implants had high dimensional accuracy and repeatability, displaying clinically acceptable morphologic similarity concerning fit and contours continuity. From a biomechanical standpoint, it was noticed that the tested implants had variable peak load values with discrete fracture patterns and failed at a mean (SD) peak load of 798.38 ± 211.45 N. In conclusion, the results of this preclinical study are in line with cranial implant expectations; however, specific attributes have scope for further improvements. View Full-Text
Keywords: alloplastic implant; biocompatible material; computer-assisted; cranioplasty; fused filament fabrication; reconstructive surgery; patient-specific modeling; printing; polymer; three-dimensional alloplastic implant; biocompatible material; computer-assisted; cranioplasty; fused filament fabrication; reconstructive surgery; patient-specific modeling; printing; polymer; three-dimensional
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MDPI and ACS Style

Sharma, N.; Aghlmandi, S.; Dalcanale, F.; Seiler, D.; Zeilhofer, H.-F.; Honigmann, P.; Thieringer, F.M. Quantitative Assessment of Point-of-Care 3D-Printed Patient-Specific Polyetheretherketone (PEEK) Cranial Implants. Int. J. Mol. Sci. 2021, 22, 8521. https://doi.org/10.3390/ijms22168521

AMA Style

Sharma N, Aghlmandi S, Dalcanale F, Seiler D, Zeilhofer H-F, Honigmann P, Thieringer FM. Quantitative Assessment of Point-of-Care 3D-Printed Patient-Specific Polyetheretherketone (PEEK) Cranial Implants. International Journal of Molecular Sciences. 2021; 22(16):8521. https://doi.org/10.3390/ijms22168521

Chicago/Turabian Style

Sharma, Neha, Soheila Aghlmandi, Federico Dalcanale, Daniel Seiler, Hans-Florian Zeilhofer, Philipp Honigmann, and Florian M. Thieringer 2021. "Quantitative Assessment of Point-of-Care 3D-Printed Patient-Specific Polyetheretherketone (PEEK) Cranial Implants" International Journal of Molecular Sciences 22, no. 16: 8521. https://doi.org/10.3390/ijms22168521

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