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Breast Cancer and Anaesthesia: Genetic Influence

1
Institute of Biomedical Research in Malaga (IBIMA), 29010 Malaga, Spain
2
Department of Anaesthesiology, Virgen de la Victoria University Hospital, 29010 Malaga, Spain
3
Department of Pharmacology and Pediatrics, School of Medicine, University of Malaga, 29010 Malaga, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Filippo Acconcia
Int. J. Mol. Sci. 2021, 22(14), 7653; https://doi.org/10.3390/ijms22147653
Received: 28 May 2021 / Revised: 5 July 2021 / Accepted: 6 July 2021 / Published: 17 July 2021
(This article belongs to the Special Issue New Drugs for Breast Cancer Treatment)
Breast cancer is the leading cause of mortality in women. It is a heterogeneous disease with a high degree of inter-subject variability even in patients with the same type of tumor, with individualized medicine having acquired significant relevance in this field. The clinical and morphological heterogeneity of the different types of breast tumors has led to a diversity of staging and classification systems. Thus, these tumors show wide variability in genetic expression and prognostic biomarkers. Surgical treatment is essential in the management of these patients. However, the perioperative period has been found to significantly influence survival and cancer recurrence. There is growing interest in the pro-tumoral effect of different anaesthetic and analgesic agents used intraoperatively and their relationship with metastatic progression. There is cumulative evidence of the influence of anaesthetic techniques on the physiopathological mechanisms of survival and growth of the residual neoplastic cells released during surgery. Prospective randomized clinical trials are needed to obtain quality evidence on the relationship between cancer and anaesthesia. This document summarizes the evidence currently available about the effects of the anaesthetic agents and techniques used in primary cancer surgery and long-term oncologic outcomes, and the biomolecular mechanisms involved in their interaction. View Full-Text
Keywords: anaesthetic drugs and techniques; opioids; propofol; volatile agent; breast cancer; cancer recurrence; biomarkers; miRNA anaesthetic drugs and techniques; opioids; propofol; volatile agent; breast cancer; cancer recurrence; biomarkers; miRNA
MDPI and ACS Style

Raigon Ponferrada, A.; Guerrero Orriach, J.L.; Molina Ruiz, J.C.; Romero Molina, S.; Gómez Luque, A.; Cruz Mañas, J. Breast Cancer and Anaesthesia: Genetic Influence. Int. J. Mol. Sci. 2021, 22, 7653. https://doi.org/10.3390/ijms22147653

AMA Style

Raigon Ponferrada A, Guerrero Orriach JL, Molina Ruiz JC, Romero Molina S, Gómez Luque A, Cruz Mañas J. Breast Cancer and Anaesthesia: Genetic Influence. International Journal of Molecular Sciences. 2021; 22(14):7653. https://doi.org/10.3390/ijms22147653

Chicago/Turabian Style

Raigon Ponferrada, Aida, Jose L. Guerrero Orriach, Juan C. Molina Ruiz, Salvador Romero Molina, Aurelio Gómez Luque, and Jose Cruz Mañas. 2021. "Breast Cancer and Anaesthesia: Genetic Influence" International Journal of Molecular Sciences 22, no. 14: 7653. https://doi.org/10.3390/ijms22147653

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