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Article

Effects of Baccharin Isolated from Brazilian Green Propolis on Adipocyte Differentiation and Hyperglycemia in ob/ob Diabetic Mice

1
Research Institute for Biological Functions, Chubu University, Kasugai, Aichi 487-8501, Japan
2
Department of Food Science, Faculty of Human Life, Jumonji University, Niiza, Saitama 352-8510, Japan
3
School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida do Café, s/n, Ribeirão Preto 14040-903, SP, Brazil
4
Department of Biological Chemistry, Chubu University, Kasugai, Aichi 487-8501, Japan
5
Laboratory of Research, Development and Innovation, Apis Flora Indl. Coml. Ltda., Ribeirão Preto 14020-670, SP, Brazil
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Benoit Gauthier
Int. J. Mol. Sci. 2021, 22(13), 6954; https://doi.org/10.3390/ijms22136954
Received: 28 May 2021 / Revised: 18 June 2021 / Accepted: 22 June 2021 / Published: 28 June 2021
(This article belongs to the Special Issue The Effect of Phytochemicals and Food Bioactive Compounds on Diabetes)
Propolis is a honeybee product with various biological activities, including antidiabetic effects. We previously reported that artepillin C, a prenylated cinnamic acid derivative isolated from Brazilian green propolis, acts as a peroxisome proliferator-activated receptor γ (PPARγ) ligand and promotes adipocyte differentiation. In this study, we examined the effect of baccharin, another major component of Brazilian green propolis, on adipocyte differentiation. The treatment of mouse 3T3-L1 preadipocytes with baccharin resulted in increased lipid accumulation, cellular triglyceride levels, glycerol-3-phosphate dehydrogenase activity, and glucose uptake. The mRNA expression levels of PPARγ and its target genes were also increased by baccharin treatment. Furthermore, baccharin enhanced PPARγ-dependent luciferase activity, suggesting that baccharin promotes adipocyte differentiation via PPARγ activation. In diabetic ob/ob mice, intraperitoneal administration of 50 mg/kg baccharin significantly improved blood glucose levels. Our results suggest that baccharin has a hypoglycemic effect on glucose metabolic disorders, such as type 2 diabetes mellitus. View Full-Text
Keywords: diabetes; propolis; baccharin; PPARγ diabetes; propolis; baccharin; PPARγ
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MDPI and ACS Style

Watanabe, A.; de Almeida, M.O.; Deguchi, Y.; Kozuka, R.; Arruda, C.; Berreta, A.A.; Bastos, J.K.; Woo, J.-T.; Yonezawa, T. Effects of Baccharin Isolated from Brazilian Green Propolis on Adipocyte Differentiation and Hyperglycemia in ob/ob Diabetic Mice. Int. J. Mol. Sci. 2021, 22, 6954. https://doi.org/10.3390/ijms22136954

AMA Style

Watanabe A, de Almeida MO, Deguchi Y, Kozuka R, Arruda C, Berreta AA, Bastos JK, Woo J-T, Yonezawa T. Effects of Baccharin Isolated from Brazilian Green Propolis on Adipocyte Differentiation and Hyperglycemia in ob/ob Diabetic Mice. International Journal of Molecular Sciences. 2021; 22(13):6954. https://doi.org/10.3390/ijms22136954

Chicago/Turabian Style

Watanabe, Akio, Marília O. de Almeida, Yusuke Deguchi, Ryuzo Kozuka, Caroline Arruda, Andresa A. Berreta, Jairo K. Bastos, Je-Tae Woo, and Takayuki Yonezawa. 2021. "Effects of Baccharin Isolated from Brazilian Green Propolis on Adipocyte Differentiation and Hyperglycemia in ob/ob Diabetic Mice" International Journal of Molecular Sciences 22, no. 13: 6954. https://doi.org/10.3390/ijms22136954

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