Virus–Host Interaction Gets Curiouser and Curiouser. PART II: Functional Transcriptomics of the E. coli DksA-Deficient Cell upon Phage P1vir Infection
Round 1
Reviewer 1 Report
Revision of manuscript ijms-1225395
Dear Authors,
Your manuscript entitled “Virus-Host Interaction Gets Curiouser and Curiouser. PART II: Functional Transcriptomics of the E. coli DksA-Deficient Cell upon Phage P1vir Infection” describes an interesting study on host-virus interaction. Authors fully and well explored, by molecular point of view, the events following P1vir phage and Wild type and DksA-deficient hosts. The abundant obtained results are interesting and, overall, well and clearly presented and discussed. The work is well planned and written.
I appreciate the style of the manuscript proposed by Authors.
Sincerely
The Reviewer
Reviewer 2 Report
The original research brings important contributions related to the P1vir development in the E. coli dksA-deficient cell. Using molecular methods the authors provided new insights regarding P1 phage biology. In absence of DksA protein, the downregulated expression of genes responsible for the P1vir lytic development (ant1 and kilA genes) could be correlated with gentle lysis. These data provide an important contribution to the field of P1 phage biology.
