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Review

Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer’s Disease: Beneficial Effects of Flavonoids for Neuroprotection

1
Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan
2
Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, Ibaraki 305-8566, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: José Luis Zugaza
Int. J. Mol. Sci. 2021, 22(11), 5719; https://doi.org/10.3390/ijms22115719
Received: 14 April 2021 / Revised: 21 May 2021 / Accepted: 25 May 2021 / Published: 27 May 2021
(This article belongs to the Special Issue Cell Signaling in Neurodegeneration 2.0)
The function of the brain-derived neurotrophic factor (BDNF) via activation through its high-affinity receptor Tropomyosin receptor kinase B (TrkB) has a pivotal role in cell differentiation, cell survival, synaptic plasticity, and both embryonic and adult neurogenesis in central nervous system neurons. A number of studies have demonstrated the possible involvement of altered expression and action of the BDNF/TrkB signaling in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD). In this review, we introduce an essential role of the BDNF and its downstream signaling in neural function. We also review the current evidence on the deregulated the BDNF signaling in the pathophysiology of AD at gene, mRNA, and protein levels. Further, we discuss a potential usefulness of small compounds, including flavonoids, which can stimulate BDNF-related signaling as a BDNF-targeting therapy. View Full-Text
Keywords: brain-derived neurotrophic factor; Alzheimer’s disease; intracellular signaling; flavonoids brain-derived neurotrophic factor; Alzheimer’s disease; intracellular signaling; flavonoids
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MDPI and ACS Style

Numakawa, T.; Odaka, H. Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer’s Disease: Beneficial Effects of Flavonoids for Neuroprotection. Int. J. Mol. Sci. 2021, 22, 5719. https://doi.org/10.3390/ijms22115719

AMA Style

Numakawa T, Odaka H. Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer’s Disease: Beneficial Effects of Flavonoids for Neuroprotection. International Journal of Molecular Sciences. 2021; 22(11):5719. https://doi.org/10.3390/ijms22115719

Chicago/Turabian Style

Numakawa, Tadahiro, and Haruki Odaka. 2021. "Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer’s Disease: Beneficial Effects of Flavonoids for Neuroprotection" International Journal of Molecular Sciences 22, no. 11: 5719. https://doi.org/10.3390/ijms22115719

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