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Article

Calcium Pyrophosphate Dihydrate Crystals Increase the Granulocyte/Monocyte Progenitor (GMP) and Enhance Granulocyte and Monocyte Differentiation In Vivo

Department of Immunology, Kanazawa Medical University, Ishikawa 920-0293, Japan
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(1), 262; https://doi.org/10.3390/ijms22010262
Received: 30 November 2020 / Revised: 20 December 2020 / Accepted: 27 December 2020 / Published: 29 December 2020
(This article belongs to the Special Issue Molecular Mechanism of Innate and Acquired Immunity in Tissue Injury)
Calcium pyrophosphate dihydrate (CPPD) crystals are formed locally within the joints, leading to pseudogout. Although the mobilization of local granulocytes can be observed in joints where pseudogout has manifested, the mechanism of this activity remains poorly understood. In this study, CPPD crystals were administered to mice, and the dynamics of splenic and peripheral blood myeloid cells were analyzed. As a result, levels of both granulocytes and monocytes were found to increase following CPPD crystal administration in a concentration-dependent manner, with a concomitant decrease in lymphocytes in the peripheral blood. In contrast, the levels of other cells, such as dendritic cell subsets, T-cells, and B-cells, remained unchanged in the spleen, following CPPD crystal administration. Furthermore, an increase in granulocytes/monocyte progenitors (GMPs) and a decrease in megakaryocyte/erythrocyte progenitors (MEPs) were also observed in the bone marrow. In addition, CPPD administration induced production of IL-1β, which acts on hematopoietic stem cells and hematopoietic progenitors and promotes myeloid cell differentiation and expansion. These results suggest that CPPD crystals act as a “danger signal” to induce IL-1β production, resulting in changes in course of hematopoietic progenitor cell differentiation and in increased granulocyte/monocyte levels, and contributing to the development of gout. View Full-Text
Keywords: calcium pyrophosphate dihydrate crystals; granulocyte; monocyte calcium pyrophosphate dihydrate crystals; granulocyte; monocyte
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MDPI and ACS Style

Onai, N.; Ogasawara, C. Calcium Pyrophosphate Dihydrate Crystals Increase the Granulocyte/Monocyte Progenitor (GMP) and Enhance Granulocyte and Monocyte Differentiation In Vivo. Int. J. Mol. Sci. 2021, 22, 262. https://doi.org/10.3390/ijms22010262

AMA Style

Onai N, Ogasawara C. Calcium Pyrophosphate Dihydrate Crystals Increase the Granulocyte/Monocyte Progenitor (GMP) and Enhance Granulocyte and Monocyte Differentiation In Vivo. International Journal of Molecular Sciences. 2021; 22(1):262. https://doi.org/10.3390/ijms22010262

Chicago/Turabian Style

Onai, Nobuyuki, and Chie Ogasawara. 2021. "Calcium Pyrophosphate Dihydrate Crystals Increase the Granulocyte/Monocyte Progenitor (GMP) and Enhance Granulocyte and Monocyte Differentiation In Vivo" International Journal of Molecular Sciences 22, no. 1: 262. https://doi.org/10.3390/ijms22010262

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