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The Significance of Lactoperoxidase System in Oral Health: Application and Efficacy in Oral Hygiene Products

1
Department of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland
2
Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(6), 1443; https://doi.org/10.3390/ijms20061443
Received: 19 February 2019 / Revised: 13 March 2019 / Accepted: 18 March 2019 / Published: 21 March 2019
(This article belongs to the Section Biochemistry)
Lactoperoxidase (LPO) present in saliva are an important element of the nonspecific immune response involved in maintaining oral health. The main role of this enzyme is to oxidize salivary thiocyanate ions (SCN) in the presence of hydrogen peroxide (H2O2) to products that exhibit antimicrobial activity. LPO derived from bovine milk has found an application in food, cosmetics, and medical industries due to its structural and functional similarity to the human enzyme. Oral hygiene products enriched with the LPO system constitute an alternative to the classic fluoride caries prophylaxis. This review describes the physiological role of human salivary lactoperoxidase and compares the results of clinical trials and in vitro studies of LPO alone and complex dentifrices enriched with bovine LPO. The role of reactivators and inhibitors of LPO is discussed together with the possibility of using nanoparticles to increase the stabilization and activity of this enzyme. View Full-Text
Keywords: lactoperoxidase; caries prophylaxis; periodontitis prophylaxis; saliva; dentifrice lactoperoxidase; caries prophylaxis; periodontitis prophylaxis; saliva; dentifrice
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MDPI and ACS Style

Magacz, M.; Kędziora, K.; Sapa, J.; Krzyściak, W. The Significance of Lactoperoxidase System in Oral Health: Application and Efficacy in Oral Hygiene Products. Int. J. Mol. Sci. 2019, 20, 1443. https://doi.org/10.3390/ijms20061443

AMA Style

Magacz M, Kędziora K, Sapa J, Krzyściak W. The Significance of Lactoperoxidase System in Oral Health: Application and Efficacy in Oral Hygiene Products. International Journal of Molecular Sciences. 2019; 20(6):1443. https://doi.org/10.3390/ijms20061443

Chicago/Turabian Style

Magacz, Marcin; Kędziora, Karolina; Sapa, Jacek; Krzyściak, Wirginia. 2019. "The Significance of Lactoperoxidase System in Oral Health: Application and Efficacy in Oral Hygiene Products" Int. J. Mol. Sci. 20, no. 6: 1443. https://doi.org/10.3390/ijms20061443

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