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Age and Sex-Dependent Differences in the Neurochemical Characterization of Calcitonin Gene-Related Peptide-Like Immunoreactive (CGRP-LI) Nervous Structures in the Porcine Descending Colon

Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowski Str. 13, 10-718 Olsztyn, Poland
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Int. J. Mol. Sci. 2019, 20(5), 1024; https://doi.org/10.3390/ijms20051024
Received: 22 January 2019 / Revised: 21 February 2019 / Accepted: 23 February 2019 / Published: 27 February 2019
(This article belongs to the Section Molecular Neurobiology)
Neurons of the enteric nervous system (ENS) may undergo changes during maturation and aging, but knowledge of physiological stimuli-dependent changes in the ENS is still fragmentary. On the other hand, the frequency of many ENS-related intestinal illnesses depends on age and/or sex. The double immunofluorescence technique was used to study the influence of both of these factors on calcitonin gene-related peptide (CGRP)—positive enteric nervous structures—in the descending colon in young and adult female and castrated male pigs. The influence of age and gender on the number and neurochemical characterization (i.e., co-localization of CGRP with substance P, nitric oxide synthase, galanin, cocaine- and amphetamine-regulated transcript peptide and vesicular acetylcholine transporter) of CGRP-positive nerve structures in the colonic wall has been shown. These observations strongly suggest the participation of CGRP in adaptive processes in the ENS during GI tract maturation. Moreover, although the castration of males may mask some aspects of sex-dependent influences on the ENS, the sex-specific differences in CGRP-positive nervous structures were mainly visible in adult animals. This may suggest that the distribution and exact role of this substance in the ENS depend on the sex hormones. View Full-Text
Keywords: calcitonin gene-related peptide; enteric nervous system; aging; sex; porcine calcitonin gene-related peptide; enteric nervous system; aging; sex; porcine
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MDPI and ACS Style

Makowska, K.; Gonkowski, S. Age and Sex-Dependent Differences in the Neurochemical Characterization of Calcitonin Gene-Related Peptide-Like Immunoreactive (CGRP-LI) Nervous Structures in the Porcine Descending Colon. Int. J. Mol. Sci. 2019, 20, 1024. https://doi.org/10.3390/ijms20051024

AMA Style

Makowska K, Gonkowski S. Age and Sex-Dependent Differences in the Neurochemical Characterization of Calcitonin Gene-Related Peptide-Like Immunoreactive (CGRP-LI) Nervous Structures in the Porcine Descending Colon. International Journal of Molecular Sciences. 2019; 20(5):1024. https://doi.org/10.3390/ijms20051024

Chicago/Turabian Style

Makowska, Krystyna; Gonkowski, Slawomir. 2019. "Age and Sex-Dependent Differences in the Neurochemical Characterization of Calcitonin Gene-Related Peptide-Like Immunoreactive (CGRP-LI) Nervous Structures in the Porcine Descending Colon" Int. J. Mol. Sci. 20, no. 5: 1024. https://doi.org/10.3390/ijms20051024

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