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Int. J. Mol. Sci. 2019, 20(3), 753; https://doi.org/10.3390/ijms20030753

Interaction among Calcium Diet Content, PTH (1-34) Treatment and Balance of Bone Homeostasis in Rat Model: The Trabecular Bone as Keystone

1
Department of Biomedical, Metabolic and Neural Sciences, Section of Human Morphology, University of Modena and Reggio Emilia, 41124 Modena, Italy
2
Department of Laboratory Medicine and Pathological Anatomy, Azienda USL of Modena, 41126 Modena, Italy
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 20 December 2018 / Revised: 22 January 2019 / Accepted: 7 February 2019 / Published: 11 February 2019
(This article belongs to the Special Issue Osteoporosis: From Molecular Mechanisms to Therapies)
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Abstract

The present study is the second step (concerning normal diet restoration) of the our previous study (concerning the calcium-free diet) to determine whether normal diet restoration, with/without concomitant PTH (1-34) administration, can influence amounts and deposition sites of the total bone mass. Histomorphometric evaluations and immunohistochemical analysis for Sclerostin expression were conducted on the vertebral bodies and femurs in the rat model. The final goals are (i) to define timing and manners of bone mass changes when calcium is restored to the diet, (ii) to analyze the different involvement of the two bony architectures having different metabolism (i.e., trabecular versus cortical bone), and (iii) to verify the eventual role of PTH (1-34) administration. Results evidenced the greater involvement of the trabecular bone with respect to the cortical bone, in response to different levels of calcium content in the diet, and the effect of PTH, mostly in the recovery of trabecular bony architecture. The main findings emerged from the present study are (i) the importance of the interplay between mineral homeostasis and skeletal homeostasis in modulating and guiding bone’s response to dietary/metabolic alterations and (ii) the evidence that the more involved bony architecture is the trabecular bone, the most susceptible to the dynamical balance of the two homeostases. View Full-Text
Keywords: calcium diet content; mineral homeostasis; skeletal homeostasis; trabecular bone; PTH (1-34); rat calcium diet content; mineral homeostasis; skeletal homeostasis; trabecular bone; PTH (1-34); rat
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ferretti, M.; Cavani, F.; Roli, L.; Checchi, M.; Magarò, M.S.; Bertacchini, J.; Palumbo, C. Interaction among Calcium Diet Content, PTH (1-34) Treatment and Balance of Bone Homeostasis in Rat Model: The Trabecular Bone as Keystone. Int. J. Mol. Sci. 2019, 20, 753.

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