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Int. J. Mol. Sci. 2019, 20(3), 464;

Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link

Department of Neural Development and Disease, Korea Brain Research Institute (KBRI), Daegu 41062, Korea
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Received: 18 January 2019 / Accepted: 19 January 2019 / Published: 22 January 2019
(This article belongs to the Special Issue Nutrition and Aging)
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Chronic neuroinflammation is a common feature of the aged brain, and its association with the major neurodegenerative changes involved in cognitive impairment and motor dysfunction is well established. One of the most potent antiaging interventions tested so far is dietary restriction (DR), which extends the lifespan in various organisms. Microglia and astrocytes are two major types of glial cells involved in the regulation of neuroinflammation. Accumulating evidence suggests that the age-related proinflammatory activation of astrocytes and microglia is attenuated under DR. However, the molecular mechanisms underlying DR-mediated regulation of neuroinflammation are not well understood. Here, we review the current understanding of the effects of DR on neuroinflammation and suggest an underlying mechanistic link between DR and neuroinflammation that may provide novel insights into the role of DR in aging and age-associated brain disorders. View Full-Text
Keywords: dietary restriction; aging; neuroinflammation; astrocytes; microglia dietary restriction; aging; neuroinflammation; astrocytes; microglia

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Bok, E.; Jo, M.; Lee, S.; Lee, B.-R.; Kim, J.; Kim, H.-J. Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link. Int. J. Mol. Sci. 2019, 20, 464.

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