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Open AccessArticle

Magnesium Sulfate Mitigates the Progression of Monocrotaline Pulmonary Hypertension in Rats

by Chao-Yuan Chang 1,2,3,†, Hung-Jen Shih 2,4,5,†, I-Tao Huang 6,7, Pei-Shan Tsai 8,9,10, Kung-Yen Chen 1,2,* and Chun-Jen Huang 1,2,3,*
1
Department of Anesthesiology, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan
2
Integrative Research Center for Critical Care, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan
3
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
4
Department of Urology, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan
5
Department of Urology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
6
Medical Education Unit, Redcliffe Hospital, Metro North Hospital and Health Service, Queensland Government, Redcliffe, QLD 4020, Australia
7
School of Public Health, Faculty of Medicine, University of Queensland, Herston, QLD 4006, Australia
8
School of Nursing, College of Nursing, Taipei Medical University, Taipei 110, Taiwan
9
Department of Nursing, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan
10
Research Center of Big Data and Meta-analysis, Wan Fang Hospital, Taipei Medical University, Taipei 116, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(18), 4622; https://doi.org/10.3390/ijms20184622
Received: 12 July 2019 / Revised: 13 September 2019 / Accepted: 16 September 2019 / Published: 18 September 2019
(This article belongs to the Special Issue Magnesium in Differentiation and Development)
We investigated whether magnesium sulfate (MgSO4) mitigated pulmonary hypertension progression in rats. Pulmonary hypertension was induced by a single intraperitoneal injection of monocrotaline (60 mg/kg). MgSO4 (100 mg/kg) was intraperitoneally administered daily for 3 weeks, from the seventh day after monocrotaline injection. Adult male rats were randomized into monocrotaline (MCT) or monocrotaline plus MgSO4 (MM) groups (n = 15 per group); control groups were maintained simultaneously. For analysis, surviving rats were euthanized on the 28th day after receiving monocrotaline. The survival rate was higher in the MM group than in the MCT group (100% versus 73.3%, p = 0.043). Levels of pulmonary artery wall thickening, α-smooth muscle actin upregulation, right ventricular systolic pressure increase, and right ventricular hypertrophy were lower in the MM group than in the MCT group (all p < 0.05). Levels of lipid peroxidation, mitochondrial injury, inflammasomes and cytokine upregulation, and apoptosis in the lungs and right ventricle were lower in the MM group than in the MCT group (all p < 0.05). Notably, the mitigation effects of MgSO4 on pulmonary artery wall thickening and right ventricular hypertrophy were counteracted by exogenous calcium chloride. In conclusion, MgSO4 mitigates pulmonary hypertension progression, possibly by antagonizing calcium. View Full-Text
Keywords: right heart failure; oxidation; mitochondria; inflammation; inflammasomes; apoptosis right heart failure; oxidation; mitochondria; inflammation; inflammasomes; apoptosis
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Chang, C.-Y.; Shih, H.-J.; Huang, I.-T.; Tsai, P.-S.; Chen, K.-Y.; Huang, C.-J. Magnesium Sulfate Mitigates the Progression of Monocrotaline Pulmonary Hypertension in Rats. Int. J. Mol. Sci. 2019, 20, 4622.

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