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Heat Shock Proteins Are Essential Components in Transformation and Tumor Progression: Cancer Cell Intrinsic Pathways and Beyond
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Heat Shock Proteins and Inflammasomes

INSERM LNC-UMR1231, University of Bourgogne Franche-Comté, 21000 Dijon, France
Platform of Transfer in Cancer Biology, Centre Georges François Leclerc, 21000 Dijon, France
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(18), 4508;
Received: 3 September 2019 / Revised: 9 September 2019 / Accepted: 10 September 2019 / Published: 12 September 2019
Heat shock proteins (HSP) regulate inflammation in many physiological contexts. However, inflammation is a broad process, involving numerous cytokines produced by different molecular pathways with multiple functions. In this review, we focused on the particular role of HSP on the inflammasomes intracellular platforms activated by danger signals and that enable activation of inflammatory caspases, mainly caspase-1, leading to the production of the pro-inflammatory cytokine IL-1β. Interestingly, some members of the HSP family favor inflammasomes activation whereas others inhibit it, suggesting that HSP modulators for therapeutic purposes, must be carefully chosen. View Full-Text
Keywords: heat shock proteins; inflammasomes; caspase-1; IL-1β heat shock proteins; inflammasomes; caspase-1; IL-1β
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Martine, P.; Rébé, C. Heat Shock Proteins and Inflammasomes. Int. J. Mol. Sci. 2019, 20, 4508.

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