Next Article in Journal
Endogenous n-3 Polyunsaturated Fatty Acids Are Beneficial to Dampen CD8+ T Cell-Mediated Inflammatory Response upon the Viral Infection in Mice
Previous Article in Journal / Special Issue
Heat Shock Proteins Are Essential Components in Transformation and Tumor Progression: Cancer Cell Intrinsic Pathways and Beyond
Open AccessReview

Heat Shock Proteins and Inflammasomes

1
INSERM LNC-UMR1231, University of Bourgogne Franche-Comté, 21000 Dijon, France
2
Platform of Transfer in Cancer Biology, Centre Georges François Leclerc, 21000 Dijon, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(18), 4508; https://doi.org/10.3390/ijms20184508
Received: 3 September 2019 / Revised: 9 September 2019 / Accepted: 10 September 2019 / Published: 12 September 2019
Heat shock proteins (HSP) regulate inflammation in many physiological contexts. However, inflammation is a broad process, involving numerous cytokines produced by different molecular pathways with multiple functions. In this review, we focused on the particular role of HSP on the inflammasomes intracellular platforms activated by danger signals and that enable activation of inflammatory caspases, mainly caspase-1, leading to the production of the pro-inflammatory cytokine IL-1β. Interestingly, some members of the HSP family favor inflammasomes activation whereas others inhibit it, suggesting that HSP modulators for therapeutic purposes, must be carefully chosen. View Full-Text
Keywords: heat shock proteins; inflammasomes; caspase-1; IL-1β heat shock proteins; inflammasomes; caspase-1; IL-1β
Show Figures

Figure 1

MDPI and ACS Style

Martine, P.; Rébé, C. Heat Shock Proteins and Inflammasomes. Int. J. Mol. Sci. 2019, 20, 4508.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

1
Back to TopTop