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Biomaterial-Based Approaches for Regeneration of Periodontal Ligament and Cementum Using 3D Platforms

by Chan Ho Park 1,2
1
Department of Dental Biomaterials, School of Dentistry, Kyungpook National University, Daegu 41940, Korea
2
Institute for Biomaterials Research and Development, Kyungpook National University, Daegu 41940, Korea
Int. J. Mol. Sci. 2019, 20(18), 4364; https://doi.org/10.3390/ijms20184364
Received: 17 July 2019 / Revised: 3 September 2019 / Accepted: 4 September 2019 / Published: 5 September 2019
Currently, various tissue engineering strategies have been developed for multiple tissue regeneration and integrative structure formations as well as single tissue formation in musculoskeletal complexes. In particular, the regeneration of periodontal tissues or tooth-supportive structures is still challenging to spatiotemporally compartmentalize PCL (poly-ε-caprolactone)-cementum constructs with micron-scaled interfaces, integrative tissue (or cementum) formations with optimal dimensions along the tooth-root surfaces, and specific orientations of engineered periodontal ligaments (PDLs). Here, we discuss current advanced approaches to spatiotemporally control PDL orientations with specific angulations and to regenerate cementum layers on the tooth-root surfaces with Sharpey’s fiber anchorages for state-of-the-art periodontal tissue engineering. View Full-Text
Keywords: biomaterials; tissue engineering; regenerative medicine; periodontal ligament; cementum; periodontal tissues biomaterials; tissue engineering; regenerative medicine; periodontal ligament; cementum; periodontal tissues
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Park, C.H. Biomaterial-Based Approaches for Regeneration of Periodontal Ligament and Cementum Using 3D Platforms. Int. J. Mol. Sci. 2019, 20, 4364.

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