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Article

Impact of Chronic BDNF Depletion on GABAergic Synaptic Transmission in the Lateral Amygdala

1
Institut für Physiologie, Otto-von-Guericke-Universität, D-39120 Magdeburg, Germany
2
Center for Behavioral Brain Sciences, D-39106 Magdeburg, Germany
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(17), 4310; https://doi.org/10.3390/ijms20174310
Received: 12 July 2019 / Revised: 30 August 2019 / Accepted: 1 September 2019 / Published: 3 September 2019
(This article belongs to the Section Molecular Neurobiology)
Brain-derived neurotrophic factor (BDNF) has previously been shown to play an important role in glutamatergic synaptic plasticity in the amygdala, correlating with cued fear learning. While glutamatergic neurotransmission is facilitated by BDNF signaling in the amygdala, its mechanism of action at inhibitory synapses in this nucleus is far less understood. We therefore analyzed the impact of chronic BDNF depletion on GABAA-mediated synaptic transmission in BDNF heterozygous knockout mice (BDNF+/−). Analysis of miniature and evoked inhibitory postsynaptic currents (IPSCs) in the lateral amygdala (LA) revealed neither pre- nor postsynaptic differences in BDNF+/− mice compared to wild-type littermates. In addition, long-term potentiation (LTP) of IPSCs was similar in both genotypes. In contrast, facilitation of spontaneous IPSCs (sIPSCs) by norepinephrine (NE) was significantly reduced in BDNF+/− mice. These results argue against a generally impaired efficacy and plasticity at GABAergic synapses due to a chronic BDNF deficit. Importantly, the increase in GABAergic tone mediated by NE is reduced in BDNF+/− mice. As release of NE is elevated during aversive behavioral states in the amygdala, effects of a chronic BDNF deficit on GABAergic inhibition may become evident in response to states of high arousal, leading to amygdala hyper-excitability and impaired amygdala function. View Full-Text
Keywords: amygdala; GABA; BDNF; heterozygous BDNF knockout mice; LTP amygdala; GABA; BDNF; heterozygous BDNF knockout mice; LTP
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MDPI and ACS Style

Meis, S.; Endres, T.; Munsch, T.; Lessmann, V. Impact of Chronic BDNF Depletion on GABAergic Synaptic Transmission in the Lateral Amygdala. Int. J. Mol. Sci. 2019, 20, 4310. https://doi.org/10.3390/ijms20174310

AMA Style

Meis S, Endres T, Munsch T, Lessmann V. Impact of Chronic BDNF Depletion on GABAergic Synaptic Transmission in the Lateral Amygdala. International Journal of Molecular Sciences. 2019; 20(17):4310. https://doi.org/10.3390/ijms20174310

Chicago/Turabian Style

Meis, Susanne, Thomas Endres, Thomas Munsch, and Volkmar Lessmann. 2019. "Impact of Chronic BDNF Depletion on GABAergic Synaptic Transmission in the Lateral Amygdala" International Journal of Molecular Sciences 20, no. 17: 4310. https://doi.org/10.3390/ijms20174310

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