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The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism

1
Department of Endocrinology and Nutrition, Germans Trias i Pujol Research Institute, 08916 Barcelona, Spain
2
Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, QLD 4111, Australia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(13), 3177; https://doi.org/10.3390/ijms20133177
Received: 13 May 2019 / Revised: 19 June 2019 / Accepted: 25 June 2019 / Published: 28 June 2019
(This article belongs to the Special Issue Perspectives on the Health Benefits of Flavonoids)
Cancer is a problem with worldwide importance and is the second leading cause of death globally. Cancer cells reprogram their metabolism to support their uncontrolled expansion by increasing biomass (anabolic metabolism—glycolysis) at the expense of their energy (bioenergetics-mitochondrial function) requirements. In this aspect, metabolic reprogramming stands out as a key biological process in understanding the conversion of a normal cell into a neoplastic precursor. Quercetin is the major representative of the flavonoid subclass of flavonols. Quercetin is ubiquitously present in fruits and vegetables, being one of the most common dietary flavonols in the western diet. The anti-cancer effects of quercetin include its ability to promote the loss of cell viability, apoptosis and autophagy through the modulation of PI3K/Akt/mTOR, Wnt/β-catenin, and MAPK/ERK1/2 pathways. In this review, we discuss the role of quercetin in cancer metabolism, addressing specifically its ability to target molecular pathways involved in glucose metabolism and mitochondrial function. View Full-Text
Keywords: quercetin; cancer; glycolysis; mitochondrial function; PI3K/Akt pathway quercetin; cancer; glycolysis; mitochondrial function; PI3K/Akt pathway
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MDPI and ACS Style

Reyes-Farias, M.; Carrasco-Pozo, C. The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism. Int. J. Mol. Sci. 2019, 20, 3177. https://doi.org/10.3390/ijms20133177

AMA Style

Reyes-Farias M, Carrasco-Pozo C. The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism. International Journal of Molecular Sciences. 2019; 20(13):3177. https://doi.org/10.3390/ijms20133177

Chicago/Turabian Style

Reyes-Farias, Marjorie, and Catalina Carrasco-Pozo. 2019. "The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism" International Journal of Molecular Sciences 20, no. 13: 3177. https://doi.org/10.3390/ijms20133177

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