Next Article in Journal
Epigenetic Mechanisms in Hepatic Stellate Cell Activation During Liver Fibrosis and Carcinogenesis
Next Article in Special Issue
Somatostatin and the “Small-For-Size” Liver
Previous Article in Journal
MST1 Regulates Neuronal Cell Death via JNK/Casp3 Signaling Pathway in HFD Mouse Brain and HT22 Cells
Version is current.
Open AccessReview

Molecular and Cellular Mechanisms Underlying Somatostatin-Based Signaling in Two Model Neural Networks, the Retina and the Hippocampus

1
Dipartimento di Biologia, Università di Pisa, 56127 Pisa, Italy
2
Dipartimento di Scienze Biomediche, Metaboliche e Neuroscienze, Università di Modena e Reggio Emilia, 41125 Modena, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(10), 2506; https://doi.org/10.3390/ijms20102506
Received: 30 April 2019 / Revised: 16 May 2019 / Accepted: 20 May 2019 / Published: 21 May 2019
(This article belongs to the Special Issue Somatostatin)
Neural inhibition plays a key role in determining the specific computational tasks of different brain circuitries. This functional “braking” activity is provided by inhibitory interneurons that use different neurochemicals for signaling. One of these substances, somatostatin, is found in several neural networks, raising questions about the significance of its widespread occurrence and usage. Here, we address this issue by analyzing the somatostatinergic system in two regions of the central nervous system: the retina and the hippocampus. By comparing the available information on these structures, we identify common motifs in the action of somatostatin that may explain its involvement in such diverse circuitries. The emerging concept is that somatostatin-based signaling, through conserved molecular and cellular mechanisms, allows neural networks to operate correctly. View Full-Text
Keywords: somatostatin; retina; hippocampus; ion channels; neurotransmitter release; neuromodulation; information flow; network activity somatostatin; retina; hippocampus; ion channels; neurotransmitter release; neuromodulation; information flow; network activity
Show Figures

Figure 1

MDPI and ACS Style

Cammalleri, M.; Bagnoli, P.; Bigiani, A. Molecular and Cellular Mechanisms Underlying Somatostatin-Based Signaling in Two Model Neural Networks, the Retina and the Hippocampus. Int. J. Mol. Sci. 2019, 20, 2506.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop