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Effect of Baicalin-Aluminum Complexes on Fecal Microbiome in Piglets

1,2,†, 1,2,†, 1,2, 1,2,*, 1,2, 1,2, 1,2, 1,2, 1,2 and 1,3
Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, China
Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan 430023, China
Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
Author to whom correspondence should be addressed.
These authors contributed equally to the work.
Int. J. Mol. Sci. 2019, 20(10), 2390;
Received: 22 April 2019 / Revised: 9 May 2019 / Accepted: 13 May 2019 / Published: 14 May 2019
(This article belongs to the Section Biochemistry)
PDF [3823 KB, uploaded 14 May 2019]


The gut microbiome has important effects on gastrointestinal diseases. Diarrhea attenuation functions of baicalin (BA) is not clear. Baicalin–aluminum complexes (BBA) were synthesized from BA, but the BBA’s efficacy on the diarrhea of piglets and the gut microbiomes have not been explored and the mechanism remains unclear. This study has explored whether BBA could modulate the composition of the gut microbiomes of piglets during diarrhea. The results showed that the diarrhea rate reduced significantly after treatment with BBA. BBA altered the overall structure of the gut microbiomes. In addition, the Gene Ontology (GO) enrichment analysis indicated that the functional differentially expressed genes, which were involved in the top 30 GO enrichments, were associated with hydrogenase (acceptor) activity, nicotinamide-nucleotide adenylyltransferase activity, and isocitrate lyase activity, belong to the molecular function. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that flagellar assembly, bacterial chemotaxis, lipopolysaccharide biosynthesis, ATP-binding cassette transporters (ABC) transporters, biosynthesis of amino acids, and phosphotransferase system (PTS) were the most enriched during BBA treatment process. Taken together, our results first demonstrated that BBA treatment could modulate the gut microbiomes composition of piglets with diarrhea, which may provide new potential insights on the mechanisms of gut microbiomes associated underlying the antimicrobial efficacy of BBA. View Full-Text
Keywords: baicalin–aluminum complexes; gut microbiomes; diarrhea baicalin–aluminum complexes; gut microbiomes; diarrhea

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Fu, S.; Zhuang, F.; Guo, L.; Qiu, Y.; Xiong, J.; Ye, C.; Liu, Y.; Wu, Z.; Hou, Y.; Hu, C.-A.A. Effect of Baicalin-Aluminum Complexes on Fecal Microbiome in Piglets. Int. J. Mol. Sci. 2019, 20, 2390.

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