Next Article in Journal
Systemic Inflammatory Response and Atherosclerosis: The Paradigm of Chronic Inflammatory Rheumatic Diseases
Previous Article in Journal
Activating the Anaphase Promoting Complex to Enhance Genomic Stability and Prolong Lifespan
 
 
Review

The Role of miR-29a in the Regulation, Function, and Signaling of Liver Fibrosis

1
Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
2
Department of Pediatrics, Chiayi Chang Gung Memorial Hospital, Chiayi County, Puzi City 613, Taiwan
3
Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
4
Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(7), 1889; https://doi.org/10.3390/ijms19071889
Received: 10 June 2018 / Revised: 23 June 2018 / Accepted: 26 June 2018 / Published: 27 June 2018
(This article belongs to the Section Biochemistry)
Both fibrosis and cirrhosis of the liver are the end results of most kinds of chronic liver damage and represent a common but difficult clinical challenge throughout the world. The inhibition of the fibrogenic, proliferative, and migratory effects of hepatic stellate cells (HSCs) has become an experimental therapy for preventing and even reversing hepatic fibrosis. Furthermore, a complete understanding of the function of non-coding RNA-mediated epigenetic mechanisms in HSC activation may improve our perception of liver fibrosis pathogenesis. This review focuses on the evolving view of the molecular mechanisms by which HSC activation by miR-29a signaling may moderate the profibrogenic phenotype of these cells, thus supporting the use of miR-29a agonists as a potential therapy for treating liver fibrosis in the future. View Full-Text
Keywords: miR-29a; cholestasis; apoptosis; endoplasmic reticulum stress; toll-like receptors; epigenetics miR-29a; cholestasis; apoptosis; endoplasmic reticulum stress; toll-like receptors; epigenetics
Show Figures

Figure 1

MDPI and ACS Style

Huang, Y.-H.; Yang, Y.-L.; Wang, F.-S. The Role of miR-29a in the Regulation, Function, and Signaling of Liver Fibrosis. Int. J. Mol. Sci. 2018, 19, 1889. https://doi.org/10.3390/ijms19071889

AMA Style

Huang Y-H, Yang Y-L, Wang F-S. The Role of miR-29a in the Regulation, Function, and Signaling of Liver Fibrosis. International Journal of Molecular Sciences. 2018; 19(7):1889. https://doi.org/10.3390/ijms19071889

Chicago/Turabian Style

Huang, Ying-Hsien, Ya-Ling Yang, and Feng-Sheng Wang. 2018. "The Role of miR-29a in the Regulation, Function, and Signaling of Liver Fibrosis" International Journal of Molecular Sciences 19, no. 7: 1889. https://doi.org/10.3390/ijms19071889

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop