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FGF Family: From Drug Development to Clinical Application

1
School of Pharmacy, Wenzhou Medical University, Chashan University Park, Wenzhou 325035, China
2
Key Laboratory Biotechnology Pharmaceutical Engineering, Wenzhou Medical University, Chashan University Park, Wenzhou 325035, China
3
State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, 308 Anshan West Road, Tianjin 300193, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(7), 1875; https://doi.org/10.3390/ijms19071875
Received: 6 May 2018 / Revised: 17 June 2018 / Accepted: 21 June 2018 / Published: 26 June 2018
(This article belongs to the Special Issue Hedgehog Signaling)
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PDF [1262 KB, uploaded 26 June 2018]
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Abstract

Fibroblast growth factor (FGF) belongs to a large family of growth factors. FGFs use paracrine or endocrine signaling to mediate a myriad of biological and pathophysiological process, including angiogenesis, wound healing, embryonic development, and metabolism regulation. FGF drugs for the treatment of burn and ulcer wounds are now available. The recent discovery of the crucial roles of the endocrine-acting FGF19 subfamily in maintaining homeostasis of bile acid, glucose, and phosphate further extended the activity profile of this family. Here, the applications of recombinant FGFs for the treatment of wounds, diabetes, hypophosphatemia, the development of FGF receptor inhibitors as anti-neoplastic drugs, and the achievements of basic research and applications of FGFs in China are reviewed. View Full-Text
Keywords: fibroblast growth factor; wound healing; metabolic regulation; fibroblast growth factor receptor inhibitor; drug development; clinical application fibroblast growth factor; wound healing; metabolic regulation; fibroblast growth factor receptor inhibitor; drug development; clinical application
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Hui, Q.; Jin, Z.; Li, X.; Liu, C.; Wang, X. FGF Family: From Drug Development to Clinical Application. Int. J. Mol. Sci. 2018, 19, 1875.

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