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Open AccessReview

The Role of Endoplasmic Reticulum Stress-Glycogen Synthase Kinase-3 Signaling in Atherogenesis

1
Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, ON L9L 2X2, Canada
2
Department of Chemistry and Chemical Biology, McMaster University, Hamilton, ON L8S 4L8, Canada
3
Department of Medicine, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(6), 1607; https://doi.org/10.3390/ijms19061607
Received: 4 May 2018 / Revised: 25 May 2018 / Accepted: 28 May 2018 / Published: 30 May 2018
(This article belongs to the Special Issue Pathomechanisms of Atherosclerosis. Part I)
Cardiovascular disease (CVD) is the number one cause of global mortality and atherosclerosis is the underlying cause of most CVD. However, the molecular mechanisms by which cardiovascular risk factors promote the development of atherosclerosis are not well understood. The development of new efficient therapies to directly block or slow disease progression will require a better understanding of these mechanisms. Accumulating evidence supports a role for endoplasmic reticulum (ER) stress in all stages of the developing atherosclerotic lesion however, it was not clear how ER stress may contribute to disease progression. Recent findings have shown that ER stress signaling through glycogen synthase kinase (GSK)-3α may significantly contribute to macrophage lipid accumulation, inflammatory cytokine production and M1macrophage polarization. In this review we summarize our knowledge of the potential role of ER stress-GSK3 signaling in the development and progression of atherosclerosis as well as the possible therapeutic implications of this pathway. View Full-Text
Keywords: atherosclerosis; risk factors; molecular mechanisms; endoplasmic reticulum (ER)-stress; glycogen synthase kinase (GSK)-3 atherosclerosis; risk factors; molecular mechanisms; endoplasmic reticulum (ER)-stress; glycogen synthase kinase (GSK)-3
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MDPI and ACS Style

Huang, A.; Patel, S.; McAlpine, C.S.; Werstuck, G.H. The Role of Endoplasmic Reticulum Stress-Glycogen Synthase Kinase-3 Signaling in Atherogenesis. Int. J. Mol. Sci. 2018, 19, 1607. https://doi.org/10.3390/ijms19061607

AMA Style

Huang A, Patel S, McAlpine CS, Werstuck GH. The Role of Endoplasmic Reticulum Stress-Glycogen Synthase Kinase-3 Signaling in Atherogenesis. International Journal of Molecular Sciences. 2018; 19(6):1607. https://doi.org/10.3390/ijms19061607

Chicago/Turabian Style

Huang, Aric; Patel, Sarvatit; McAlpine, Cameron S.; Werstuck, Geoff H. 2018. "The Role of Endoplasmic Reticulum Stress-Glycogen Synthase Kinase-3 Signaling in Atherogenesis" Int. J. Mol. Sci. 19, no. 6: 1607. https://doi.org/10.3390/ijms19061607

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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