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Int. J. Mol. Sci. 2018, 19(4), 1256;

Ca2+ Regulation of TRP Ion Channels

Department of Pharmaceutical Sciences, College of Pharmacy Mercer University, Atlanta, GA 30341, USA
School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK
Author to whom correspondence should be addressed.
Received: 29 March 2018 / Revised: 16 April 2018 / Accepted: 17 April 2018 / Published: 23 April 2018
(This article belongs to the Special Issue Calcium Binding Proteins)
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Ca2+ signaling influences nearly every aspect of cellular life. Transient receptor potential (TRP) ion channels have emerged as cellular sensors for thermal, chemical and mechanical stimuli and are major contributors to Ca2+ signaling, playing an important role in diverse physiological and pathological processes. Notably, TRP ion channels are also one of the major downstream targets of Ca2+ signaling initiated either from TRP channels themselves or from various other sources, such as G-protein coupled receptors, giving rise to feedback regulation. TRP channels therefore function like integrators of Ca2+ signaling. A growing body of research has demonstrated different modes of Ca2+-dependent regulation of TRP ion channels and the underlying mechanisms. However, the precise actions of Ca2+ in the modulation of TRP ion channels remain elusive. Advances in Ca2+ regulation of TRP channels are critical to our understanding of the diversified functions of TRP channels and complex Ca2+ signaling. View Full-Text
Keywords: TRP ion channels; Ca2+ signaling; calmodulin; phosphatidylinositol-4,5-biphosphate (PIP2) TRP ion channels; Ca2+ signaling; calmodulin; phosphatidylinositol-4,5-biphosphate (PIP2)

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Hasan, R.; Zhang, X. Ca2+ Regulation of TRP Ion Channels. Int. J. Mol. Sci. 2018, 19, 1256.

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