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Int. J. Mol. Sci. 2018, 19(4), 1083;

Teleosts Genomics: Progress and Prospects in Disease Prevention and Control

Norwegian University of Life Sciences, Faculty of Veterinary Medicine and Biosciences, Department of Basic Sciences and Aquatic Medicine, Section of Aquatic Medicine and Nutrition, Adamstuen Campus, Ullevålsveien 72, P.O. Box 8146, Dep NO-0033, 0464 Oslo, Norway
Department of Cell Biology and Histology, Faculty of Biology, Institute of Biomedical Research of Murcia-Arrixaca, Campus Universitario de Espinardo, University of Murcia, 30100 Murcia, Spain
Department of Animal Sciences, R.H. Smith Faculty of Agriculture, Food and Environment The Hebrew University of Jerusalem P.O. Box 12, Rehovot 76100, Israel
Author to whom correspondence should be addressed.
Received: 21 January 2018 / Revised: 11 March 2018 / Accepted: 29 March 2018 / Published: 4 April 2018
(This article belongs to the Section Biochemistry)
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Genome wide studies based on conventional molecular tools and upcoming omics technologies are beginning to gain functional applications in the control and prevention of diseases in teleosts fish. Herein, we provide insights into current progress and prospects in the use genomics studies for the control and prevention of fish diseases. Metagenomics has emerged to be an important tool used to identify emerging infectious diseases for the timely design of rational disease control strategies, determining microbial compositions in different aquatic environments used for fish farming and the use of host microbiota to monitor the health status of fish. Expounding the use of antimicrobial peptides (AMPs) as therapeutic agents against different pathogens as well as elucidating their role in tissue regeneration is another vital aspect of genomics studies that had taken precedent in recent years. In vaccine development, prospects made include the identification of highly immunogenic proteins for use in recombinant vaccine designs as well as identifying gene signatures that correlate with protective immunity for use as benchmarks in optimizing vaccine efficacy. Progress in quantitative trait loci (QTL) mapping is beginning to yield considerable success in identifying resistant traits against some of the highly infectious diseases that have previously ravaged the aquaculture industry. Altogether, the synopsis put forth shows that genomics studies are beginning to yield positive contribution in the prevention and control of fish diseases in aquaculture. View Full-Text
Keywords: antimicrobial; disease; genomics; immunity; metagenomics; protection; vaccines antimicrobial; disease; genomics; immunity; metagenomics; protection; vaccines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Munang’andu, H.M.; Galindo-Villegas, J.; David, L. Teleosts Genomics: Progress and Prospects in Disease Prevention and Control. Int. J. Mol. Sci. 2018, 19, 1083.

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