Next Article in Journal
Radiation-Induced Gene Expression Changes in High and Low Grade Breast Cancer Cell Types
Previous Article in Journal
Loss of ISWI Function in Drosophila Nuclear Bodies Drives Cytoplasmic Redistribution of Drosophila TDP-43
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2018, 19(4), 1083; https://doi.org/10.3390/ijms19041083

Teleosts Genomics: Progress and Prospects in Disease Prevention and Control

1
Norwegian University of Life Sciences, Faculty of Veterinary Medicine and Biosciences, Department of Basic Sciences and Aquatic Medicine, Section of Aquatic Medicine and Nutrition, Adamstuen Campus, Ullevålsveien 72, P.O. Box 8146, Dep NO-0033, 0464 Oslo, Norway
2
Department of Cell Biology and Histology, Faculty of Biology, Institute of Biomedical Research of Murcia-Arrixaca, Campus Universitario de Espinardo, University of Murcia, 30100 Murcia, Spain
3
Department of Animal Sciences, R.H. Smith Faculty of Agriculture, Food and Environment The Hebrew University of Jerusalem P.O. Box 12, Rehovot 76100, Israel
*
Author to whom correspondence should be addressed.
Received: 21 January 2018 / Revised: 11 March 2018 / Accepted: 29 March 2018 / Published: 4 April 2018
(This article belongs to the Section Biochemistry)
Full-Text   |   PDF [348 KB, uploaded 3 May 2018]

Abstract

Genome wide studies based on conventional molecular tools and upcoming omics technologies are beginning to gain functional applications in the control and prevention of diseases in teleosts fish. Herein, we provide insights into current progress and prospects in the use genomics studies for the control and prevention of fish diseases. Metagenomics has emerged to be an important tool used to identify emerging infectious diseases for the timely design of rational disease control strategies, determining microbial compositions in different aquatic environments used for fish farming and the use of host microbiota to monitor the health status of fish. Expounding the use of antimicrobial peptides (AMPs) as therapeutic agents against different pathogens as well as elucidating their role in tissue regeneration is another vital aspect of genomics studies that had taken precedent in recent years. In vaccine development, prospects made include the identification of highly immunogenic proteins for use in recombinant vaccine designs as well as identifying gene signatures that correlate with protective immunity for use as benchmarks in optimizing vaccine efficacy. Progress in quantitative trait loci (QTL) mapping is beginning to yield considerable success in identifying resistant traits against some of the highly infectious diseases that have previously ravaged the aquaculture industry. Altogether, the synopsis put forth shows that genomics studies are beginning to yield positive contribution in the prevention and control of fish diseases in aquaculture. View Full-Text
Keywords: antimicrobial; disease; genomics; immunity; metagenomics; protection; vaccines antimicrobial; disease; genomics; immunity; metagenomics; protection; vaccines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Munang’andu, H.M.; Galindo-Villegas, J.; David, L. Teleosts Genomics: Progress and Prospects in Disease Prevention and Control. Int. J. Mol. Sci. 2018, 19, 1083.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top