Evolution of Influenza A Virus by Mutation and Re-Assortment
AbstractInfluenza A virus (IAV), a highly infectious respiratory pathogen, has continued to be a significant threat to global public health. To complete their life cycle, influenza viruses have evolved multiple strategies to interact with a host. A large number of studies have revealed that the evolution of influenza A virus is mainly mediated through the mutation of the virus itself and the re-assortment of viral genomes derived from various strains. The evolution of influenza A virus through these mechanisms causes worldwide annual epidemics and occasional pandemics. Importantly, influenza A virus can evolve from an animal infected pathogen to a human infected pathogen. The highly pathogenic influenza virus has resulted in stupendous economic losses due to its morbidity and mortality both in human and animals. Influenza viruses fall into a category of viruses that can cause zoonotic infection with stable adaptation to human, leading to sustained horizontal transmission. The rapid mutations of influenza A virus result in the loss of vaccine optimal efficacy, and challenge the complete eradication of the virus. In this review, we highlight the current understanding of influenza A virus evolution caused by the mutation and re-assortment of viral genomes. In addition, we discuss the specific mechanisms by which the virus evolves. View Full-Text
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Shao, W.; Li, X.; Goraya, M.U.; Wang, S.; Chen, J.-L. Evolution of Influenza A Virus by Mutation and Re-Assortment. Int. J. Mol. Sci. 2017, 18, 1650.
Shao W, Li X, Goraya MU, Wang S, Chen J-L. Evolution of Influenza A Virus by Mutation and Re-Assortment. International Journal of Molecular Sciences. 2017; 18(8):1650.Chicago/Turabian Style
Shao, Wenhan; Li, Xinxin; Goraya, Mohsan U.; Wang, Song; Chen, Ji-Long. 2017. "Evolution of Influenza A Virus by Mutation and Re-Assortment." Int. J. Mol. Sci. 18, no. 8: 1650.
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