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PGK1 Drives Hepatocellular Carcinoma Metastasis by Enhancing Metabolic Process

College of Traditional Chinese medicine, Jinan University, Guangzhou 510632, China
Department of Pathology, Guangdong Provincial Key Laboratory of Molecular Tumor Pathology and School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2017, 18(8), 1630;
Received: 16 May 2017 / Revised: 12 July 2017 / Accepted: 22 July 2017 / Published: 27 July 2017
(This article belongs to the Special Issue Chemical and Molecular Approach to Tumor Metastases)
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During the proliferation and metastasis, the tumor cells prefer glycolysis (Warburg effect), but its exact mechanism remains largely unknown. In this study, we demonstrated that phosphoglycerate kinase 1 (PGK1) is an important enzyme in the pathway of metabolic glycolysis. We observed a significant overexpression of PGK1 in hepatocellular carcinoma tissues, and a correlation between PGK1 expression and poor survival of hepatocellular carcinoma patients. Also, the depletion of PGK1 dramatically reduced cancer cell proliferation and metastasis, indicating an oncogenic role of PGK1 in liver cancer progression. Further experiments showed that PGK1 played an important role in MYC-induced metabolic reprogramming, which led to an enhanced Warburg effect. Our results revealed a new effect of PGK1, which can provide a new treatment strategy for hepatocellular carcinoma, as PGK1 is used to indicate the prognosis of hepatocellular carcinoma (HCC). View Full-Text
Keywords: PGK1; MYC; hepatocellular carcinoma; metastasis; Warburg effect PGK1; MYC; hepatocellular carcinoma; metastasis; Warburg effect

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Xie, H.; Tong, G.; Zhang, Y.; Liang, S.; Tang, K.; Yang, Q. PGK1 Drives Hepatocellular Carcinoma Metastasis by Enhancing Metabolic Process. Int. J. Mol. Sci. 2017, 18, 1630.

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