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Int. J. Mol. Sci. 2017, 18(7), 1426;

Effect of Oxidative Stress on Cardiovascular System in Response to Gravity

Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan
Department of Medicine, Okayama University, Okayama 700-8558, Japan
Department of Cardiovascular Surgery, Harbin Medical University, Harbin 150001, China
Author to whom correspondence should be addressed.
Received: 1 June 2017 / Revised: 26 June 2017 / Accepted: 27 June 2017 / Published: 4 July 2017
(This article belongs to the Special Issue Oxidative Stress and Space Biology: An Organ-Based Approach)
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Long-term habitation in space leads to physiological alterations such as bone loss, muscle atrophy, and cardiovascular deconditioning. Two predominant factors—namely space radiation and microgravity—have a crucial impact on oxidative stress in living organisms. Oxidative stress is also involved in the aging process, and plays important roles in the development of cardiovascular diseases including hypertension, left ventricular hypertrophy, and myocardial infarction. Here, we discuss the effects of space radiation, microgravity, and a combination of these two factors on oxidative stress. Future research may facilitate safer living in space by reducing the adverse effects of oxidative stress. View Full-Text
Keywords: oxidative stress; reactive oxygen species; radiation; microgravity oxidative stress; reactive oxygen species; radiation; microgravity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Takahashi, K.; Okumura, H.; Guo, R.; Naruse, K. Effect of Oxidative Stress on Cardiovascular System in Response to Gravity. Int. J. Mol. Sci. 2017, 18, 1426.

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