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Int. J. Mol. Sci. 2017, 18(6), 1273;

Hormesis and Defense of Infectious Disease

Department of Anesthesiology and Intensive Care Medicine, University Hospital Jena, Jena 07747, Germany
Center for Infectious Diseases and Infection Control, University Hospital Jena, Jena 07747, Germany
Center for Sepsis Control and Care, University Hospital Jena, Jena 07747, Germany
Institute of Molecular Cell Biology, Center for Molecular Biomedicine (CMB), University Hospital Jena, Jena 07745, Germany
Fritz Lipmann Institute, Leibniz Institute on Aging, Jena 07745, Germany
Author to whom correspondence should be addressed.
Academic Editor: Guido R. M. M. Haenen
Received: 18 April 2017 / Revised: 16 May 2017 / Accepted: 20 May 2017 / Published: 15 June 2017
(This article belongs to the Special Issue Hormesis and Transhormesis in Toxicology and Risk Assessment)
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Infectious diseases are a global health burden and remain associated with high social and economic impact. Treatment of affected patients largely relies on antimicrobial agents that act by directly targeting microbial replication. Despite the utility of host specific therapies having been assessed in previous clinical trials, such as targeting the immune response via modulating the cytokine release in sepsis, results have largely been frustrating and did not lead to the introduction of new therapeutic tools. In this article, we will discuss current evidence arguing that, by applying the concept of hormesis, already approved pharmacological agents could be used therapeutically to increase survival of patients with infectious disease via improving disease tolerance, a defense mechanism that decreases the extent of infection-associated tissue damage without directly targeting pathogenic microorganisms. View Full-Text
Keywords: tissue damage; tolerance; hormesis; sepsis; DNA damage tissue damage; tolerance; hormesis; sepsis; DNA damage

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Weis, S.; Rubio, I.; Ludwig, K.; Weigel, C.; Jentho, E. Hormesis and Defense of Infectious Disease. Int. J. Mol. Sci. 2017, 18, 1273.

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