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Int. J. Mol. Sci. 2017, 18(6), 1263;

Expression of Salivary miR-203a-3p Was Related with Oral Health-Related Quality of Life in Healthy Volunteers

Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan
Department of Community Oral Health, Asahi University of Dentistry, 1851-1 Hozumi, Mizuho, Gifu 501-0296, Japan
Center of Innovative Clinical Medicine, Okayama University Hospital, Okayama 700-8558, Japan
Author to whom correspondence should be addressed.
Received: 9 May 2017 / Revised: 6 June 2017 / Accepted: 8 June 2017 / Published: 13 June 2017
(This article belongs to the Special Issue microRNA Regulation 2017)
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Oral health-related quality of life (OHRQoL) is a multidimensional construct that involves subjective evaluation of an individual’s oral health. Although it is difficult to evaluate OHRQoL biologically, recently, it has been reported that circulating microRNAs (miRNAs) in several body fluids could reflect various health conditions. The aim of this pilot study was to investigate whether salivary miRNAs expression differs according to OHRQoL in healthy volunteers. Forty-six volunteers (median age, 23.0 years) were recruited, and their OHRQoL was assessed using the Japanese version of the Oral Health Impact Profile (OHIP-J). Then, we compared salivary microRNA profiles of the high-OHRQoL group (≤25th percentile score of OHIP-J) and the low-OHRQoL group (≥75th percentile score of OHIP-J) using the polymerase chain reaction (PCR) array and the quantitative real-time PCR. There were no significant differences between the two groups in terms of oral health status. In the PCR array, miR-203a-3p and miR-30b-5p were significantly more expressed in the low-OHRQoL group (p < 0.05). Quantitative real-time PCR assay also showed that miR-203a-3p was more highly expressed in the low-OHRQoL group than in the high-OHRQoL group (p < 0.05). These observations suggest that expression of salivary miR-203a-3p was related with OHRQoL in healthy volunteers. View Full-Text
Keywords: biomarkers; microRNA; saliva; oral health-related quality of life biomarkers; microRNA; saliva; oral health-related quality of life

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Kobayashi, T.; Tomofuji, T.; Machida, T.; Yoneda, T.; Ekuni, D.; Azuma, T.; Maruyama, T.; Hirose, A.; Morita, M. Expression of Salivary miR-203a-3p Was Related with Oral Health-Related Quality of Life in Healthy Volunteers. Int. J. Mol. Sci. 2017, 18, 1263.

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