Next Article in Journal
C1q/TNF-Related Protein-9 Ameliorates Ox-LDL-Induced Endothelial Dysfunction via PGC-1α/AMPK-Mediated Antioxidant Enzyme Induction
Next Article in Special Issue
Interactive Roles of DNA Helicases and Translocases with the Single-Stranded DNA Binding Protein RPA in Nucleic Acid Metabolism
Previous Article in Journal
Therapeutic Applications of Rose Hips from Different Rosa Species
Previous Article in Special Issue
Applying Broadband Dielectric Spectroscopy (BDS) for the Biophysical Characterization of Mammalian Tissues under a Variety of Cellular Stresses
Open AccessReview

Perturbations in the Replication Program Contribute to Genomic Instability in Cancer

1
Department of Microbiology and Molecular Genetics, IMRIC, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel
2
Pharmacology and Experimental Therapeutics Unit, The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
*
Author to whom correspondence should be addressed.
Academic Editor: Vassilis G. Gorgoulis
Int. J. Mol. Sci. 2017, 18(6), 1138; https://doi.org/10.3390/ijms18061138
Received: 6 April 2017 / Revised: 8 May 2017 / Accepted: 21 May 2017 / Published: 25 May 2017
(This article belongs to the Special Issue Mechanisms Leading to Genomic Instability)
Cancer and genomic instability are highly impacted by the deoxyribonucleic acid (DNA) replication program. Inaccuracies in DNA replication lead to the increased acquisition of mutations and structural variations. These inaccuracies mainly stem from loss of DNA fidelity due to replication stress or due to aberrations in the temporal organization of the replication process. Here we review the mechanisms and impact of these major sources of error to the replication program. View Full-Text
Keywords: genomic instability; replication timing; replication stress; cancer genomic instability; replication timing; replication stress; cancer
Show Figures

Figure 1

MDPI and ACS Style

Blumenfeld, B.; Ben-Zimra, M.; Simon, I. Perturbations in the Replication Program Contribute to Genomic Instability in Cancer. Int. J. Mol. Sci. 2017, 18, 1138.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop