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Int. J. Mol. Sci. 2017, 18(11), 2351; https://doi.org/10.3390/ijms18112351

Autophagy Roles in the Modulation of DNA Repair Pathways

Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-900, SP, Brazil
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Received: 29 September 2017 / Revised: 27 October 2017 / Accepted: 1 November 2017 / Published: 7 November 2017
(This article belongs to the Special Issue Autophagy at the Intersection of the Immune System and Cancer)
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Abstract

Autophagy and DNA repair are biological processes vital for cellular homeostasis maintenance and when dysfunctional, they lead to several human disorders including premature aging, neurodegenerative diseases, and cancer. The interchange between these pathways is complex and it may occur in both directions. Autophagy is activated in response to several DNA lesions types and it can regulate different mechanisms and molecules involved in DNA damage response (DDR), such as cell cycle checkpoints, cell death, and DNA repair. Thus, autophagy may modulate DNA repair pathways, the main focus of this review. In addition to the already well-documented autophagy positive effects on homologous recombination (HR), autophagy has also been implicated with other DNA repair mechanisms, such as base excision repair (BER), nucleotide excision repair (NER), and mismatch repair (MMR). Given the relevance of these cellular processes, the clinical applications of drugs targeting this autophagy-DNA repair interface emerge as potential therapeutic strategies for many diseases, especially cancer. View Full-Text
Keywords: autophagy; DNA repair; homologous recombination (HR); non-homologous end joining (NHEJ); base excision repair (BER); nucleotide excision repair (NER) autophagy; DNA repair; homologous recombination (HR); non-homologous end joining (NHEJ); base excision repair (BER); nucleotide excision repair (NER)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Gomes, L.R.; Menck, C.F.M.; Leandro, G.S. Autophagy Roles in the Modulation of DNA Repair Pathways. Int. J. Mol. Sci. 2017, 18, 2351.

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