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Role of Placental VDR Expression and Function in Common Late Pregnancy Disorders

Department of Obstetrics and Gynecology, University Hospital, Ludwig-Maximilians Universität München, 80337 Munich, Germany
Department of Obstetrics and Gynecology, Klinik Hallerwiese, 90419 Nürnberg, Germany
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2017, 18(11), 2340;
Received: 26 September 2017 / Revised: 24 October 2017 / Accepted: 26 October 2017 / Published: 6 November 2017
PDF [709 KB, uploaded 6 November 2017]


Vitamin D, besides its classical role in bone metabolism, plays a distinct role in multiple pathways of the feto-maternal unit. Calcitriol is the major active ligand of the nuclear vitamin D receptor (VDR). The vitamin D receptor (VDR) is expressed in different uteroplacental parts and exerts a variety of functions in physiologic pregnancy. It regulates decidualisation and implantation, influences hormone secretion and placental immune modulations. This review highlights the role of the vitamin D receptor in physiologic and disturbed pregnancy, as preeclampsia, fetal growth restriction, gestational diabetes and preterm birth. We discuss the existing literature regarding common VDR polymorphisms in these pregnancy disorders. View Full-Text
Keywords: vitamin D; VDR; preterm birth; GDM; preeclampsia; fetal growth restriction vitamin D; VDR; preterm birth; GDM; preeclampsia; fetal growth restriction

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Knabl, J.; Vattai, A.; Ye, Y.; Jueckstock, J.; Hutter, S.; Kainer, F.; Mahner, S.; Jeschke, U. Role of Placental VDR Expression and Function in Common Late Pregnancy Disorders. Int. J. Mol. Sci. 2017, 18, 2340.

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