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Int. J. Mol. Sci. 2016, 17(9), 1439;

Adhesion, Proliferation and Migration of NIH/3T3 Cells on Modified Polyaniline Surfaces

Centre of Polymer Systems, Tomas Bata University in Zlín, třída Tomáše Bati 5678, 760 01 Zlín, Czech Republic
Author to whom correspondence should be addressed.
Academic Editor: Iolanda Francolini
Received: 28 July 2016 / Revised: 28 July 2016 / Accepted: 26 August 2016 / Published: 15 September 2016
(This article belongs to the Section Materials Science)
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Polyaniline shows great potential and promises wide application in the biomedical field thanks to its intrinsic conductivity and material properties, which closely resemble natural tissues. Surface properties are crucial, as these predetermine any interaction with biological fluids, proteins and cells. An advantage of polyaniline is the simple modification of its surface, e.g., by using various dopant acids. An investigation was made into the adhesion, proliferation and migration of mouse embryonic fibroblasts on pristine polyaniline films and films doped with sulfamic and phosphotungstic acids. In addition, polyaniline films supplemented with poly (2-acrylamido-2-methyl-1-propanesulfonic) acid at various ratios were tested. Results showed that the NIH/3T3 cell line was able to adhere, proliferate and migrate on the pristine polyaniline films as well as those films doped with sulfamic and phosphotungstic acids; thus, utilization of said forms in biomedicine appears promising. Nevertheless, incorporating poly (2-acrylamido-2-methyl-1-propanesulfonic) acid altered the surface properties of the polyaniline films and significantly affected cell behavior. In order to reveal the crucial factor influencing the surface/cell interaction, cell behavior is discussed in the context of the surface energy of individual samples. It was clearly demonstrated that the lesser the difference between the surface energy of the sample and cell, the more cyto-compatible the surface is. View Full-Text
Keywords: polyaniline; fibroblast; cyto-compatibility; sulfamic acid; phosphotungstic acid; poly (2-acrylamido-2-methyl-1-propanesulfonic) acid polyaniline; fibroblast; cyto-compatibility; sulfamic acid; phosphotungstic acid; poly (2-acrylamido-2-methyl-1-propanesulfonic) acid

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Rejmontová, P.; Capáková, Z.; Mikušová, N.; Maráková, N.; Kašpárková, V.; Lehocký, M.; Humpolíček, P. Adhesion, Proliferation and Migration of NIH/3T3 Cells on Modified Polyaniline Surfaces. Int. J. Mol. Sci. 2016, 17, 1439.

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