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Open AccessArticle

Development of a Three-Dimensional (3D) Printed Biodegradable Cage to Convert Morselized Corticocancellous Bone Chips into a Structured Cortical Bone Graft

1
Department of Mechanical Engineering, Chang Gung University, Taoyuan 33302, Taiwan
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Department of Orthopedics, Chang Gung Memorial Hospital, Taoyuan 33375, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Ihtesham ur Rehman
Int. J. Mol. Sci. 2016, 17(4), 595; https://doi.org/10.3390/ijms17040595
Received: 15 March 2016 / Revised: 1 April 2016 / Accepted: 11 April 2016 / Published: 20 April 2016
(This article belongs to the Special Issue Molecular Research on Dental Materials and Biomaterials)
This study aimed to develop a new biodegradable polymeric cage to convert corticocancellous bone chips into a structured strut graft for treating segmental bone defects. A total of 24 adult New Zealand white rabbits underwent a left femoral segmental bone defect creation. Twelve rabbits in group A underwent three-dimensional (3D) printed cage insertion, corticocancellous chips implantation, and Kirschner-wire (K-wire) fixation, while the other 12 rabbits in group B received bone chips implantation and K-wire fixation only. All rabbits received a one-week activity assessment and the initial image study at postoperative 1 week. The final image study was repeated at postoperative 12 or 24 weeks before the rabbit scarification procedure on schedule. After the animals were sacrificed, both femurs of all the rabbits were prepared for leg length ratios and 3-point bending tests. The rabbits in group A showed an increase of activities during the first week postoperatively and decreased anterior cortical disruptions in the postoperative image assessments. Additionally, higher leg length ratios and 3-point bending strengths demonstrated improved final bony ingrowths within the bone defects for rabbits in group A. In conclusion, through this bone graft converting technique, orthopedic surgeons can treat segmental bone defects by using bone chips but with imitate characters of structured cortical bone graft. View Full-Text
Keywords: biodegradable bone cage; 3D printing; polylactide (PLA); corticocancellous chips; structured strut bone graft biodegradable bone cage; 3D printing; polylactide (PLA); corticocancellous chips; structured strut bone graft
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MDPI and ACS Style

Chou, Y.-C.; Lee, D.; Chang, T.-M.; Hsu, Y.-H.; Yu, Y.-H.; Liu, S.-J.; Ueng, S.W.-N. Development of a Three-Dimensional (3D) Printed Biodegradable Cage to Convert Morselized Corticocancellous Bone Chips into a Structured Cortical Bone Graft. Int. J. Mol. Sci. 2016, 17, 595.

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