Next Article in Journal
Individual Assessment of Brain Tissue Changes in MS and the Effect of Focal Lesions on Short-Term Focal Atrophy Development in MS: A Voxel-Guided Morphometry Study
Next Article in Special Issue
DNA Damage: A Main Determinant of Vascular Aging
Previous Article in Journal
The Impact of Specific Viruses on Clinical Outcome in Children Presenting with Acute Heart Failure
Previous Article in Special Issue
Epigenetic Modifications in Essential Hypertension
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2016, 17(4), 480;

High Salt Diet Affects Renal Sodium Excretion and ERRα Expression

Department of Cardiovascular Medicine, First Affiliated Hospital of Medical College of Xi’an Jiaotong University, Key Laboratory of Molecular Cardiology, No. 277 Yanta West Road, Xi’an 710061, China
Author to whom correspondence should be addressed.
Academic Editor: Anastasia Susie Mihailidou
Received: 29 February 2016 / Revised: 24 March 2016 / Accepted: 25 March 2016 / Published: 1 April 2016
(This article belongs to the Special Issue Molecular Research on Hypertension)
Full-Text   |   PDF [6702 KB, uploaded 1 April 2016]   |  


Kidneys regulate the balance of water and sodium and therefore are related to blood pressure. It is unclear whether estrogen-related receptor α (ERRα), an orphan nuclear receptor and transcription factor highly expressed in kidneys, affects the reabsorption of water and sodium. The aim of this study was to determine whether changes in the expressions of ERRα, Na+/K+-ATPase and epithelial sodium channel (ENaC) proteins affected the reabsorption of water and sodium in kidneys of Dahl salt-sensitive (DS) rats. SS.13BN rats, 98% homologous to the DS rats, were used as a normotensive control group. The 24 h urinary sodium excretion of the DS and SS.13BN rats increased after the 6-week high salt diet intervention, while sodium excretion was increased in DS rats with daidzein (agonist of ERRα) treatment. ERRα expression was decreased, while β- and γ-ENaC mRNA expressions were increased upon high sodium diet treatment in the DS rats. In the chromatin immunoprecipitation (CHIP) assay, positive PCR signals were obtained in samples treated with anti-ERRα antibody. The transcriptional activity of ERRα was decreased upon high salt diet intervention. ERRα reduced the expressions of β- and γ-ENaC by binding to the ENaC promoter, thereby increased Na+ reabsorption. Therefore, ERRα might be one of the factors causing salt-sensitive hypertension. View Full-Text
Keywords: sodium; potassium; estrogen-related receptor α; salt sensitive sodium; potassium; estrogen-related receptor α; salt sensitive

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Wang, D.; Wang, Y.; Liu, F.-Q.; Yuan, Z.-Y.; Mu, J.-J. High Salt Diet Affects Renal Sodium Excretion and ERRα Expression. Int. J. Mol. Sci. 2016, 17, 480.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top