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Int. J. Mol. Sci. 2016, 17(2), 230;

Endocannabinoids as Guardians of Metastasis

Institute of Clinical Pharmacology, University Hospital Frankfurt, Germany
Received: 16 November 2015 / Revised: 24 December 2015 / Accepted: 1 February 2016 / Published: 10 February 2016
(This article belongs to the Collection Feature Annual Reviews in Molecular Sciences)
PDF [602 KB, uploaded 17 February 2016]


Endocannabinoids including anandamide and 2-arachidonoylglycerol are involved in cancer pathophysiology in several ways, including tumor growth and progression, peritumoral inflammation, nausea and cancer pain. Recently we showed that the endocannabinoid profiles are deranged during cancer to an extent that this manifests in alterations of plasma endocannabinoids in cancer patients, which was mimicked by similar changes in rodent models of local and metastatic cancer. The present topical review summarizes the complexity of endocannabinoid signaling in the context of tumor growth and metastasis. View Full-Text
Keywords: endocannabinoids; anandamide; 2-arachidonoylglycerol; orphan G-protein coupled receptor; immune cells; angiogenesis endocannabinoids; anandamide; 2-arachidonoylglycerol; orphan G-protein coupled receptor; immune cells; angiogenesis

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Tegeder, I. Endocannabinoids as Guardians of Metastasis. Int. J. Mol. Sci. 2016, 17, 230.

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