Next Article in Journal
Sanger Sequencing for BRCA1 c.68_69del, BRCA1 c.5266dup and BRCA2 c.5946del Mutation Screen on Pap Smear Cytology Samples
Previous Article in Journal
Chemically Induced Reprogramming of Somatic Cells to Pluripotent Stem Cells and Neural Cells
Article

Identification of Novel Pathways in Plant Lectin-Induced Cancer Cell Apoptosis

by 1,†, 2,†, 1,†, 1, 1, 2, 1,* and 3,*
1
School of Basic Medical & Nursing School, Chengdu University, Chengdu 610106, China
2
School of Life Sciences and Key Laboratory of Bio-resources, Ministry of Education, Sichuan University, Chengdu 610064, China
3
School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2016, 17(2), 228; https://doi.org/10.3390/ijms17020228
Received: 14 December 2015 / Revised: 30 January 2016 / Accepted: 2 February 2016 / Published: 8 February 2016
(This article belongs to the Section Biochemistry)
Plant lectins have been investigated to elucidate their complicated mechanisms due to their remarkable anticancer activities. Although plant lectins seems promising as a potential anticancer agent for further preclinical and clinical uses, further research is still urgently needed and should include more focus on molecular mechanisms. Herein, a Naïve Bayesian model was developed to predict the protein-protein interaction (PPI), and thus construct the global human PPI network. Moreover, multiple sources of biological data, such as smallest shared biological process (SSBP), domain-domain interaction (DDI), gene co-expression profiles and cross-species interolog mapping were integrated to build the core apoptotic PPI network. In addition, we further modified it into a plant lectin-induced apoptotic cell death context. Then, we identified 22 apoptotic hub proteins in mesothelioma cells according to their different microarray expressions. Subsequently, we used combinational methods to predict microRNAs (miRNAs) which could negatively regulate the abovementioned hub proteins. Together, we demonstrated the ability of our Naïve Bayesian model-based network for identifying novel plant lectin-treated cancer cell apoptotic pathways. These findings may provide new clues concerning plant lectins as potential apoptotic inducers for cancer drug discovery. View Full-Text
Keywords: plant lectin; apoptosis; Naïve Bayesian model; novel pathways; cancer plant lectin; apoptosis; Naïve Bayesian model; novel pathways; cancer
Show Figures

Graphical abstract

MDPI and ACS Style

Shi, Z.; Sun, R.; Yu, T.; Liu, R.; Cheng, L.-J.; Bao, J.-K.; Zou, L.; Tang, Y. Identification of Novel Pathways in Plant Lectin-Induced Cancer Cell Apoptosis. Int. J. Mol. Sci. 2016, 17, 228. https://doi.org/10.3390/ijms17020228

AMA Style

Shi Z, Sun R, Yu T, Liu R, Cheng L-J, Bao J-K, Zou L, Tang Y. Identification of Novel Pathways in Plant Lectin-Induced Cancer Cell Apoptosis. International Journal of Molecular Sciences. 2016; 17(2):228. https://doi.org/10.3390/ijms17020228

Chicago/Turabian Style

Shi, Zheng, Rong Sun, Tian Yu, Rong Liu, Li-Jia Cheng, Jin-Ku Bao, Liang Zou, and Yong Tang. 2016. "Identification of Novel Pathways in Plant Lectin-Induced Cancer Cell Apoptosis" International Journal of Molecular Sciences 17, no. 2: 228. https://doi.org/10.3390/ijms17020228

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop