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Focus on Extracellular Vesicles: Therapeutic Potential of Stem Cell-Derived Extracellular Vesicles
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Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer

1
Division of Cancer Biology and Therapeutics, Departments of Surgery, Biomedical Sciences and Pathology and Laboratory Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
2
Experimental Pharmacology Unit, Department of Research, IRCCS-Istituto Nazionale Tumori Fondazione G. Pascale, 80131 Naples, Italy
3
Department of Experimental and Clinical Biomedical Science, University of Florence, 50121 Florence, Italy
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Istituto Nazionale Genetica Molecolare “Romeo ed Enrica Invernizzi”, 20122 Milan, Italy
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The Urological Diseases Research Center, Boston Children’s Hospital, Boston, MA 02115, USA
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Department of Surgery, Harvard Medical School, Boston, MA 02115, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2016, 17(2), 175; https://doi.org/10.3390/ijms17020175
Received: 12 August 2015 / Accepted: 16 October 2015 / Published: 6 February 2016
(This article belongs to the Special Issue Focus on Extracellular Vesicles)
Extracellular Vesicles (EVs) have received considerable attention in recent years, both as mediators of intercellular communication pathways that lead to tumor progression, and as potential sources for discovery of novel cancer biomarkers. For many years, research on EVs has mainly investigated either the mechanism of biogenesis and cargo selection and incorporation, or the methods of EV isolation from available body fluids for biomarker discovery. Recent studies have highlighted the existence of different populations of cancer-derived EVs, with distinct molecular cargo, thus pointing to the possibility that the various EV populations might play diverse roles in cancer and that this does not happen randomly. However, data attributing cancer specific intercellular functions to given populations of EVs are still limited. A deeper functional, biochemical and molecular characterization of the various EV classes might identify more selective clinical markers, and significantly advance our knowledge of the pathogenesis and disease progression of many cancer types. View Full-Text
Keywords: extracellular vesicles; exosomes; ectosomes; large oncosomes; microvesicles; cancer; intercellular communication; tumor microenvironment extracellular vesicles; exosomes; ectosomes; large oncosomes; microvesicles; cancer; intercellular communication; tumor microenvironment
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Ciardiello, C.; Cavallini, L.; Spinelli, C.; Yang, J.; Reis-Sobreiro, M.; De Candia, P.; Minciacchi, V.R.; Di Vizio, D. Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer. Int. J. Mol. Sci. 2016, 17, 175.

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