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Int. J. Mol. Sci. 2016, 17(12), 2107;

α-Tocopherol and Hippocampal Neural Plasticity in Physiological and Pathological Conditions

Department of Biomolecular Sciences, University of Urbino, 61029 Urbino, Italy
Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy
Author to whom correspondence should be addressed.
Academic Editors: Rafat A. Siddiqui, Maria Laura Colombo and Laura Di Renzo
Received: 14 October 2016 / Revised: 1 December 2016 / Accepted: 9 December 2016 / Published: 15 December 2016
(This article belongs to the Special Issue Tocopherols and Tocotrienols: Metabolism and Properties)
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Neuroplasticity is an “umbrella term” referring to the complex, multifaceted physiological processes that mediate the ongoing structural and functional modifications occurring, at various time- and size-scales, in the ever-changing immature and adult brain, and that represent the basis for fundamental neurocognitive behavioral functions; in addition, maladaptive neuroplasticity plays a role in the pathophysiology of neuropsychiatric dysfunctions. Experiential cues and several endogenous and exogenous factors can regulate neuroplasticity; among these, vitamin E, and in particular α-tocopherol (α-T), the isoform with highest bioactivity, exerts potent effects on many plasticity-related events in both the physiological and pathological brain. In this review, the role of vitamin E/α-T in regulating diverse aspects of neuroplasticity is analyzed and discussed, focusing on the hippocampus, a brain structure that remains highly plastic throughout the lifespan and is involved in cognitive functions. Vitamin E-mediated influences on hippocampal synaptic plasticity and related cognitive behavior, on post-natal development and adult hippocampal neurogenesis, as well as on cellular and molecular disruptions in kainate-induced temporal seizures are described. Besides underscoring the relevance of its antioxidant properties, non-antioxidant functions of vitamin E/α-T, mainly involving regulation of cell signaling molecules and their target proteins, have been highlighted to help interpret the possible mechanisms underlying the effects on neuroplasticity. View Full-Text
Keywords: vitamin E; brain; neuroplasticity; development; adult neurogenesis; seizures vitamin E; brain; neuroplasticity; development; adult neurogenesis; seizures

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Ambrogini, P.; Betti, M.; Galati, C.; Di Palma, M.; Lattanzi, D.; Savelli, D.; Galli, F.; Cuppini, R.; Minelli, A. α-Tocopherol and Hippocampal Neural Plasticity in Physiological and Pathological Conditions. Int. J. Mol. Sci. 2016, 17, 2107.

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