Next Article in Journal
Preparation of a Bis-GMA-Free Dental Resin System with Synthesized Fluorinated Dimethacrylate Monomers
Next Article in Special Issue
Secondary Structure Adopted by the Gly-Gly-X Repetitive Regions of Dragline Spider Silk
Previous Article in Journal
Cytokinins and Expression of SWEET, SUT, CWINV and AAP Genes Increase as Pea Seeds Germinate
Previous Article in Special Issue
Importance of Heat and Pressure for Solubilization of Recombinant Spider Silk Proteins in Aqueous Solution
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2016, 17(12), 2012;

Natural Non-Mulberry Silk Nanoparticles for Potential-Controlled Drug Release

National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China
College of Chemistry and Chemical Engineering and Biological Engineering, Donghua University, Shanghai 201620, China
Department of Biotechnology, Indian Institute of Technology Kharagpur, West Bengal 721302, India
Author to whom correspondence should be addressed.
Academic Editors: John G. Hardy and Chris Holland
Received: 12 October 2016 / Revised: 25 November 2016 / Accepted: 26 November 2016 / Published: 1 December 2016
(This article belongs to the Special Issue Silk-Based Materials: From Production to Characterization)
Full-Text   |   PDF [3415 KB, uploaded 1 December 2016]   |  


Natural silk protein nanoparticles are a promising biomaterial for drug delivery due to their pleiotropic properties, including biocompatibility, high bioavailability, and biodegradability. Chinese oak tasar Antheraea pernyi silk fibroin (ApF) nanoparticles are easily obtained using cations as reagents under mild conditions. The mild conditions are potentially advantageous for the encapsulation of sensitive drugs and therapeutic molecules. In the present study, silk fibroin protein nanoparticles are loaded with differently-charged small-molecule drugs, such as doxorubicin hydrochloride, ibuprofen, and ibuprofen-Na, by simple absorption based on electrostatic interactions. The structure, morphology and biocompatibility of the silk nanoparticles in vitro are investigated. In vitro release of the drugs from the nanoparticles depends on charge-charge interactions between the drugs and the nanoparticles. The release behavior of the compounds from the nanoparticles demonstrates that positively-charged molecules are released in a more prolonged or sustained manner. Cell viability studies with L929 demonstrated that the ApF nanoparticles significantly promoted cell growth. The results suggest that Chinese oak tasar Antheraea pernyi silk fibroin nanoparticles can be used as an alternative matrix for drug carrying and controlled release in diverse biomedical applications. View Full-Text
Keywords: Antheraea pernyi silk fibroin; nanoparticles; controlled drug release Antheraea pernyi silk fibroin; nanoparticles; controlled drug release

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Wang, J.; Yin, Z.; Xue, X.; Kundu, S.C.; Mo, X.; Lu, S. Natural Non-Mulberry Silk Nanoparticles for Potential-Controlled Drug Release. Int. J. Mol. Sci. 2016, 17, 2012.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top