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Int. J. Mol. Sci. 2015, 16(4), 6902-6910;

Anti-Inflammatory Effect of Streptochlorin via TRIF-Dependent Signaling Pathways in Cellular and Mouse Models

Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju 380-150, Korea
Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science & Technology, 787 Haeanro, Ansan 426-744, Korea
Division of Biological Science and Technology, Yonsei University, Wonju 222-710, Korea
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 10 February 2015 / Revised: 7 March 2015 / Accepted: 16 March 2015 / Published: 26 March 2015
(This article belongs to the Special Issue Bioactivity of Marine Natural Products)
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Streptochlorin, a small compound derived from marine actinomycete, has been shown to have anti-angiogenic, anti-tumor, and anti-allergic activities. However, the anti-inflammatory effects and underlying mechanisms have not yet been reported. In the present study, we investigated the effect of streptochlorin on lipopolysaccharide (LPS)-induced inflammatory responses in vitro and in vivo. Streptochlorin attenuated the production of proinflammatory mediators such as nitric oxide, cyclooxygenase-2, pro-interleukin (IL)-1β, and IL-6 in LPS-stimulated RAW264.7 cells through inhibition of the Toll/interleukin-1 receptor (TIR)-domain-containing adapter-inducing interferon-β (TRIF)-dependent signaling pathway. Furthermore, streptochlorin suppressed the infiltration of immune cells such as neutrophils into the lung and proinflammatory cytokine production such as IL-6 and TNF-α in broncho-alveolar lavage fluid (BALF) in the LPS-induced acute lung injury (ALI) mouse model. Streptochlorin has potent anti-inflammatory effects through regulating TRIF-dependent signaling pathways, suggesting that streptochlorin may provide a valuable therapeutic strategy in treating various inflammatory diseases. View Full-Text
Keywords: streptochlorin; LPS; anti-inflammation; TRIF; ALI streptochlorin; LPS; anti-inflammation; TRIF; ALI

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Shim, D.-W.; Shin, H.J.; Han, J.-W.; Shin, W.-Y.; Sun, X.; Shim, E.-J.; Kim, T.-J.; Kang, T.-B.; Lee, K.-H. Anti-Inflammatory Effect of Streptochlorin via TRIF-Dependent Signaling Pathways in Cellular and Mouse Models. Int. J. Mol. Sci. 2015, 16, 6902-6910.

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