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Int. J. Mol. Sci. 2015, 16(3), 6298-6311;

Genotyping Test with Clinical Factors: Better Management of Acute Postoperative Pain?

Laboratoire de Pharmacologie, Pharmacie Clinique et Contrôle de Qualité des Médicaments, Faculté de Pharmacie, Saint-Joseph University of Beirut, B.P. 11-5076-Riad El Solh, Beirut 1107 2180, Lebanon
Université Paris Descartes, Unité INSERM UMR-S 1144, Paris F-75006, France
Department of Anesthesia and Critical Care, Hôtel-Dieu de France Hospital-Saint-Joseph University of Beirut, B.P. 16-6830, Beirut 1100 2160, Lebanon
Author to whom correspondence should be addressed.
Academic Editor: Sabrina Angelini
Received: 12 January 2015 / Revised: 12 February 2015 / Accepted: 2 March 2015 / Published: 19 March 2015
(This article belongs to the Special Issue Pharmacogenetics and Personalized Medicine)
Full-Text   |   PDF [762 KB, uploaded 19 March 2015]   |  


Individualization of acute postoperative pain treatment on an evidence-based decision process is a major health concern. The aim of this study is to investigate the influence of genetic and non-genetic factors on the variability of response to morphine in acute postoperative pain. A group of nighty-five patients undergoing major surgery were included prospectively. At 24 h, a logistic regression model was carried out to determine the factors associated with morphine doses given by a Patient Controlled Analgesia device. The dose of morphine was associated with age (p = 0.011), patient weight (p = 0.025) and the duration of operation (p = 0.030). This dose decreased with patient’s age and duration of operation and increased with patient’s weight. OPRM1 and ABCB1 polymorphisms were significantly associated with administered dose of morphine (p = 0.038 and 0.012 respectively). Patients with at least one G allele for c.118A>G OPRM1 polymorphism (AG/GG) needed 4 times the dose of morphine of AA patients. Additionally, patients with ABCB1 CT and CC genotypes for c.3435C>T polymorphism were 5.6 to 7.1 times more prone to receive higher dose of morphine than TT patients. Our preliminary results support the evidence that OPRM1/ABCB1 genotypes along with age, weight and duration of operation have an impact on morphine consumption for acute postoperative pain treatment. View Full-Text
Keywords: morphine; polymorphism; OPRM1; ABCB1; pain; pharmacogenetics morphine; polymorphism; OPRM1; ABCB1; pain; pharmacogenetics

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Hajj, A.; Peoc'h, K.; Laplanche, J.-L.; Jabbour, H.; Naccache, N.; Zeid, H.A.; Yazbeck, P.; Khabbaz, L.R. Genotyping Test with Clinical Factors: Better Management of Acute Postoperative Pain? Int. J. Mol. Sci. 2015, 16, 6298-6311.

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