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Review

Induced Pluripotent Stem Cells and Their Use in Cardiac and Neural Regenerative Medicine

Department of Histology and Embryology, Medical Faculty in Hradec Kralove, Charles University in Prague, Simkova 870, Hradec Kralove 50038, Czech Republic
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Francesc Cebrià
Int. J. Mol. Sci. 2015, 16(2), 4043-4067; https://doi.org/10.3390/ijms16024043
Received: 29 December 2014 / Revised: 27 January 2015 / Accepted: 2 February 2015 / Published: 13 February 2015
(This article belongs to the Special Issue Molecular and Cellular Basis of Regeneration and Tissue Repair)
Stem cells are unique pools of cells that are crucial for embryonic development and maintenance of adult tissue homeostasis. The landmark Nobel Prize winning research by Yamanaka and colleagues to induce pluripotency in somatic cells has reshaped the field of stem cell research. The complications related to the usage of pluripotent embryonic stem cells (ESCs) in human medicine, particularly ESC isolation and histoincompatibility were bypassed with induced pluripotent stem cell (iPSC) technology. The human iPSCs can be used for studying embryogenesis, disease modeling, drug testing and regenerative medicine. iPSCs can be diverted to different cell lineages using small molecules and growth factors. In this review we have focused on iPSC differentiation towards cardiac and neuronal lineages. Moreover, we deal with the use of iPSCs in regenerative medicine and modeling diseases like myocardial infarction, Timothy syndrome, dilated cardiomyopathy, Parkinson’s, Alzheimer’s and Huntington’s disease. Despite the promising potential of iPSCs, genome contamination and low efficacy of cell reprogramming remain significant challenges. View Full-Text
Keywords: iPS cells; cell reprogramming; directed differentiation; Parkinson’s disease; Alzheimer’s disease; Huntington’s disease iPS cells; cell reprogramming; directed differentiation; Parkinson’s disease; Alzheimer’s disease; Huntington’s disease
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MDPI and ACS Style

Skalova, S.; Svadlakova, T.; Qureshi, W.M.S.; Dev, K.; Mokry, J. Induced Pluripotent Stem Cells and Their Use in Cardiac and Neural Regenerative Medicine. Int. J. Mol. Sci. 2015, 16, 4043-4067. https://doi.org/10.3390/ijms16024043

AMA Style

Skalova S, Svadlakova T, Qureshi WMS, Dev K, Mokry J. Induced Pluripotent Stem Cells and Their Use in Cardiac and Neural Regenerative Medicine. International Journal of Molecular Sciences. 2015; 16(2):4043-4067. https://doi.org/10.3390/ijms16024043

Chicago/Turabian Style

Skalova, Stepanka, Tereza Svadlakova, Wasay M.S. Qureshi, Kapil Dev, and Jaroslav Mokry. 2015. "Induced Pluripotent Stem Cells and Their Use in Cardiac and Neural Regenerative Medicine" International Journal of Molecular Sciences 16, no. 2: 4043-4067. https://doi.org/10.3390/ijms16024043

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