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Int. J. Mol. Sci. 2015, 16(2), 3298-3306;

Norcembranoidal Diterpenes from the Cultured-Type Octocoral Sinularia numerosa

Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Michael R. Hamblin
Received: 20 December 2014 / Revised: 23 January 2015 / Accepted: 30 January 2015 / Published: 3 February 2015
(This article belongs to the Section Biochemistry)
Full-Text   |   PDF [837 KB, uploaded 3 February 2015]   |  


A known norcembranoidal diterpene, 5-episinuleptolide (1), along with a new analogue, 4α-hydroxy-5-episinuleptolide (2), were isolated from a cultured-type soft coral Sinularia numerosa. The structures of 1 and 2 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1 and 2 against a panel of tumor cells is also described. Compound 2 exhibited moderate cytotoxicity toward CCRF-CEM cells with an IC50 value 4.21 μg/mL. Preliminary SAR (structure activity relationship) information was obtained from these two compounds. View Full-Text
Keywords: sinuleptolide; cembranoidal diterpene; Sinularia numerosa; cytotoxicity sinuleptolide; cembranoidal diterpene; Sinularia numerosa; cytotoxicity

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Chen, W.-F.; Yin, C.-T.; Cheng, C.-H.; Lu, M.-C.; Fang, L.-S.; Wang, W.-H.; Wen, Z.-H.; Chen, J.-J.; Wu, Y.-C.; Sung, P.-J. Norcembranoidal Diterpenes from the Cultured-Type Octocoral Sinularia numerosa. Int. J. Mol. Sci. 2015, 16, 3298-3306.

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