Next Article in Journal
Recovering Bioactive Compounds from Olive Oil Filter Cake by Advanced Extraction Techniques
Next Article in Special Issue
Emodin Ameliorates LPS-Induced Acute Lung Injury, Involving the Inactivation of NF-κB in Mice
Previous Article in Journal
SP600125 Induces Src and Type I IGF Receptor Phosphorylation Independent of JNK
Previous Article in Special Issue
Overexpression of Shox2 Leads to Congenital Dysplasia of the Temporomandibular Joint in Mice
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2014, 15(9), 16257-16269;

FOXO1, TGF-β Regulation and Wound Healing

School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Department of Stomatology, the 4th Hospital of Hebei Medical University, Shijiazhuang 050011, China
Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Author to whom correspondence should be addressed.
Received: 7 April 2014 / Revised: 13 August 2014 / Accepted: 14 August 2014 / Published: 15 September 2014
(This article belongs to the Special Issue Signal Transduction of Tissue Repair)
Full-Text   |   PDF [1037 KB, uploaded 15 September 2014]   |  


Re-epithelialization is a complex process that involves migration and proliferation of keratinocytes, in addition to the production of cytokines and growth factors that affect other cells. The induction of transcription factors during these processes is crucial for successful wound healing. The transcription factor forkhead boxO-1 (FOXO1) has recently been found to be an important regulator of wound healing. In particular, FOXO1 has significant effects through regulation of transforming growth factor-beta (TGF-β) expression and protecting keratinocytes from oxidative stress. In the absence of FOXO1, there is increased oxidative damage, reduced TGF-β1 expression, reduced migration and proliferation of keratinocytes and increased keratinocytes apoptosis leading to impaired re-epithelialization of wounds. View Full-Text
Keywords: cell death; epithelial; FOXO; transforming growth factor-beta; migration; proliferation; repair; ROS; skin; wound cell death; epithelial; FOXO; transforming growth factor-beta; migration; proliferation; repair; ROS; skin; wound

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Hameedaldeen, A.; Liu, J.; Batres, A.; Graves, G.S.; Graves, D.T. FOXO1, TGF-β Regulation and Wound Healing. Int. J. Mol. Sci. 2014, 15, 16257-16269.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top