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Open AccessReview

Increased Circulatory Asymmetric Dimethylarginine and Multiple Organ Failure: Bile Duct Ligation in Rat as a Model

by Jiunn-Ming Sheen 1,2,†, Yu-Chieh Chen 1,†, You-Lin Tain 1,3,* and Li-Tung Huang 1,3,*
1
Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
2
Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan
3
Department of Traditional Chinese Medicine, Chang Gung University, Linkou 244, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2014, 15(3), 3989-4006; https://doi.org/10.3390/ijms15033989
Received: 5 December 2013 / Revised: 4 February 2014 / Accepted: 26 February 2014 / Published: 5 March 2014
(This article belongs to the Special Issue ADMA and Nitrergic System)
Bile duct ligation (BDL)-treated rats exhibit cholestasis, increased systemic oxidative stress, and liver fibrosis, which ultimately lead to liver cirrhosis. Asymmetric dimethylarginine (ADMA) is a competitive inhibitor of nitric oxide synthase that can decrease the synthesis of nitric oxide. BDL rats have higher plasma and hepatic ADMA levels, which may be due to increased hepatic protein arginine methyltransferase-1 and decreased dimethylarginine dimethylaminohydrolase expression. BDL rats also exhibit renal and brain damage characterized by increased tissue ADMA concentrations. The increased plasma ADMA levels and multiple organ damages seen here are also observed following multiple organ failures associated with critical illness. This review discusses the dysregulation of ADMA in major organs in BDL rats and the role of increased ADMA in multiple organ damages. View Full-Text
Keywords: asymmetric dimethylarginine; bile duct ligation; cholestasis; oxidative stress; multiple organ failure asymmetric dimethylarginine; bile duct ligation; cholestasis; oxidative stress; multiple organ failure
MDPI and ACS Style

Sheen, J.-M.; Chen, Y.-C.; Tain, Y.-L.; Huang, L.-T. Increased Circulatory Asymmetric Dimethylarginine and Multiple Organ Failure: Bile Duct Ligation in Rat as a Model. Int. J. Mol. Sci. 2014, 15, 3989-4006.

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