Next Article in Journal
Beyond the Role of Dietary Protein and Amino Acids in the Prevention of Diet-Induced Obesity
Next Article in Special Issue
Exploring the Molecular Basis for Selective Binding of Homoserine Dehydrogenase from Mycobacterium leprae TN toward Inhibitors: A Virtual Screening Study
Previous Article in Journal
Development of Molecularly Imprinted Polymer in Porous Film Format for Binding of Phenol and Alkylphenols from Water
Previous Article in Special Issue
Multi-Scale Computational Enzymology: Enhancing Our Understanding of Enzymatic Catalysis
Open AccessReview

In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors

1
School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
2
State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2014, 15(1), 1358-1373; https://doi.org/10.3390/ijms15011358
Received: 10 December 2013 / Revised: 2 January 2014 / Accepted: 7 January 2014 / Published: 20 January 2014
Aminoacyl-tRNA synthetases (aaRSs) are enzymes that catalyze the transfer of amino acids to their cognate tRNA. They play a pivotal role in protein synthesis and are essential for cell growth and survival. The aaRSs are one of the leading targets for development of antibiotic agents. In this review, we mainly focused on aaRS inhibitor discovery and development using in silico methods including virtual screening and structure-based drug design. These computational methods are relatively fast and cheap, and are proving to be of great benefit for the rational development of more potent aaRS inhibitors and other pharmaceutical agents that may usher in a much needed generation of new antibiotics. View Full-Text
Keywords: aminoacyl-tRNA synthetase; inhibitor; antibiotics; virtual screening; structure-based drug design; docking aminoacyl-tRNA synthetase; inhibitor; antibiotics; virtual screening; structure-based drug design; docking
MDPI and ACS Style

Zhao, Y.; Meng, Q.; Bai, L.; Zhou, H. In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors. Int. J. Mol. Sci. 2014, 15, 1358-1373.

AMA Style

Zhao Y, Meng Q, Bai L, Zhou H. In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors. International Journal of Molecular Sciences. 2014; 15(1):1358-1373.

Chicago/Turabian Style

Zhao, Yaxue; Meng, Qingqing; Bai, Linquan; Zhou, Huchen. 2014. "In Silico Discovery of Aminoacyl-tRNA Synthetase Inhibitors" Int. J. Mol. Sci. 15, no. 1: 1358-1373.

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop