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Anti-Inflammatory Activity of N-(3-Florophenyl)ethylcaffeamide in Mice

School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Department of Health and Nutrition Biotechnology, College of Health Science, Asia University, Taichung 404, Taiwan
Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
Nihon Pharmaceutica University, Saitama 362-0806, Japan
Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2013, 14(8), 15199-15211;
Received: 4 June 2013 / Revised: 4 July 2013 / Accepted: 16 July 2013 / Published: 24 July 2013
(This article belongs to the Section Biochemistry)
PDF [311 KB, uploaded 19 June 2014]


In this study, we evaluated the anti-inflammatory activity of one synthetic product, N-(3-Florophenyl)ethylcaffeamide (abbrev. FECA), by using animal model of λ-carrageenan-induced paw edema in mice. The anti-inflammatory mechanism of FECA was determined by measuring the levels of cyclooxygenase-2 (COX-2), nitric oxide (NO), tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), and malondialdehyde (MDA) in the edema paw tissue, and the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GRd) in the liver. The results showed that FECA reduced the paw edema at three, four and five hours after λ-carrageenan administration. The levels of COX-2, NO, TNF-α, and MDA in the λ-carrageenan-induced edema paws were reduced and the activities of SOD, GPx, and GRd in liver tissues were raised by FECA. These results suggested that FECA possessed anti-inflammatory activities and the anti-inflammatory mechanisms might be related to the decrease of the levels of COX-2, NO, and TNF-α in inflamed tissues and the increase in the MDA level by increasing the activities of SOD, GPx, and GRd. View Full-Text
Keywords: anti-inflammatory; caffeamide; synthesis anti-inflammatory; caffeamide; synthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Liao, J.-C.; Tsai, J.-C.; Peng, W.-H.; Chiu, Y.-J.; Sung, P.-J.; Tsuzoki, M.; Kuo, Y.-H. Anti-Inflammatory Activity of N-(3-Florophenyl)ethylcaffeamide in Mice. Int. J. Mol. Sci. 2013, 14, 15199-15211.

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