Next Article in Journal
Modulation by Melatonin of the Pathogenesis of Inflammatory Autoimmune Diseases
Next Article in Special Issue
Versatile Redox Chemistry Complicates Antioxidant Capacity Assessment: Flavonoids as Milieu-Dependent Anti- and Pro-Oxidants
Previous Article in Journal
Wharton’s Jelly-Derived Mesenchymal Stem Cells: Phenotypic Characterization and Optimizing Their Therapeutic Potential for Clinical Applications
Previous Article in Special Issue
The Physiological Importance of Glucosinolates on Plant Response to Abiotic Stress in Brassica
Review

Towards a Molecular Understanding of the Biosynthesis of Amaryllidaceae Alkaloids in Support of Their Expanding Medical Use

Plant Biochemistry Laboratory, Department of Plant and Environmental Sciences, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg, Denmark
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2013, 14(6), 11713-11741; https://doi.org/10.3390/ijms140611713
Received: 28 April 2013 / Revised: 26 May 2013 / Accepted: 27 May 2013 / Published: 31 May 2013
(This article belongs to the Special Issue Molecular Research in Plant Secondary Metabolism)
The alkaloids characteristically produced by the subfamily Amaryllidoideae of the Amaryllidaceae, bulbous plant species that include well know genera such as Narcissus (daffodils) and Galanthus (snowdrops), are a source of new pharmaceutical compounds. Presently, only the Amaryllidaceae alkaloid galanthamine, an acetylcholinesterase inhibitor used to treat symptoms of Alzheimer’s disease, is produced commercially as a drug from cultivated plants. However, several Amaryllidaceae alkaloids have shown great promise as anti-cancer drugs, but their further clinical development is restricted by their limited commercial availability. Amaryllidaceae species have a long history of cultivation and breeding as ornamental bulbs, and phytochemical research has focussed on the diversity in alkaloid content and composition. In contrast to the available pharmacological and phytochemical data, ecological, physiological and molecular aspects of the Amaryllidaceae and their alkaloids are much less explored and the identity of the alkaloid biosynthetic genes is presently unknown. An improved molecular understanding of Amaryllidaceae alkaloid biosynthesis would greatly benefit the rational design of breeding programs to produce cultivars optimised for the production of pharmaceutical compounds and enable biotechnology based approaches. View Full-Text
Keywords: Amaryllidaceae; alkaloids; galanthamine; lycorine; narciclasine; Narcissus; Galanthus; Lycoris Amaryllidaceae; alkaloids; galanthamine; lycorine; narciclasine; Narcissus; Galanthus; Lycoris
Show Figures

Graphical abstract

MDPI and ACS Style

Takos, A.M.; Rook, F. Towards a Molecular Understanding of the Biosynthesis of Amaryllidaceae Alkaloids in Support of Their Expanding Medical Use. Int. J. Mol. Sci. 2013, 14, 11713-11741. https://doi.org/10.3390/ijms140611713

AMA Style

Takos AM, Rook F. Towards a Molecular Understanding of the Biosynthesis of Amaryllidaceae Alkaloids in Support of Their Expanding Medical Use. International Journal of Molecular Sciences. 2013; 14(6):11713-11741. https://doi.org/10.3390/ijms140611713

Chicago/Turabian Style

Takos, Adam M., and Fred Rook. 2013. "Towards a Molecular Understanding of the Biosynthesis of Amaryllidaceae Alkaloids in Support of Their Expanding Medical Use" International Journal of Molecular Sciences 14, no. 6: 11713-11741. https://doi.org/10.3390/ijms140611713

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop