Next Article in Journal
Comparative in Vivo Assessment of Some Adverse Bioeffects of Equidimensional Gold and Silver Nanoparticles and the Attenuation of Nanosilver’s Effects with a Complex of Innocuous Bioprotectors
Next Article in Special Issue
Maintenance of Genomic Stability in Mouse Embryonic Stem Cells: Relevance in Aging and Disease
Previous Article in Journal
Melatonin Anticancer Effects: Review
Previous Article in Special Issue
Parkinson’s Disease: A Complex Interplay of Mitochondrial DNA Alterations and Oxidative Stress
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2013, 14(2), 2431-2448;

The Yin-Yang of DNA Damage Response: Roles in Tumorigenesis and Cellular Senescence

Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110001, China
Department of Medical Oncology, The Fourth Affiliated Hospital, China Medical University, Shenyang 110032, China
Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong
Radiation Medicine Branch, National Cancer Center, Goyang, Gyenggi 410-769, Korea
Authors to whom correspondence should be addressed.
Received: 16 November 2012 / Revised: 8 January 2013 / Accepted: 9 January 2013 / Published: 25 January 2013
(This article belongs to the Special Issue DNA Damage and Repair in Degenerative Diseases)
Full-Text   |   PDF [394 KB, uploaded 19 June 2014]


Senescent cells are relatively stable, lacking proliferation capacity yet retaining metabolic activity. In contrast, cancer cells are rather invasive and devastating, with uncontrolled proliferative capacity and resistance to cell death signals. Although tumorigenesis and cellular senescence are seemingly opposite pathological events, they are actually driven by a unified mechanism: DNA damage. Integrity of the DNA damage response (DDR) network can impose a tumorigenesis barrier by navigating abnormal cells to cellular senescence. Compromise of DDR, possibly due to the inactivation of DDR components, may prevent cellular senescence but at the expense of tumor formation. Here we provide an overview of the fundamental role of DDR in tumorigenesis and cellular senescence, under the light of the Yin-Yang concept of Chinese philosophy. Emphasis is placed on discussing DDR outcome in the light of in vivo models. This information is critical as it can help make better decisions for clinical treatments of cancer patients. View Full-Text
Keywords: DNA damage response; cell cycle arrest; tumorigenesis; senescence DNA damage response; cell cycle arrest; tumorigenesis; senescence
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Li, X.; Xu, H.; Xu, C.; Lin, M.; Song, X.; Yi, F.; Feng, Y.; Coughlan, K.A.; Cho, W.C.-S.; Kim, S.S.; Cao, L. The Yin-Yang of DNA Damage Response: Roles in Tumorigenesis and Cellular Senescence. Int. J. Mol. Sci. 2013, 14, 2431-2448.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top