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Article

NF-κB-Targeted Anti-Inflammatory Activity of Prunella vulgaris var. lilacina in Macrophages RAW 264.7

1
Department of Agrofood Resources, National Academy of Agricultural Science, RDA, Suwon, Gyeonggi-do 441-853, Korea
2
Department of Biotechnology & Bioengineering, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2013, 14(11), 21489-21503; https://doi.org/10.3390/ijms141121489
Received: 24 August 2013 / Revised: 29 September 2013 / Accepted: 23 October 2013 / Published: 30 October 2013
(This article belongs to the Section Biochemistry)
Prunella vulgaris var. lilacina, a herbal medicine, has long been used in Korea for the treatment of sore throat, and to alleviate fever and accelerate wound healing. Although the therapeutic effect of P. vulgaris var. lilacina is likely associated with anti-inflammatory activity, the precise underlying mechanisms are largely unknown. Here, we sought to elucidate the possible mechanisms of the anti-inflammatory activity. We have investigated the anti-inflammatory activity of the various solvent fractions (hexane, butanol, chloroform and water) from the ethanol extract of P. vulgaris var. lilacina in activated macrophages. The hexane fraction exhibited higher anti-inflammatory activities, inducing inhibition of nitric oxide and prostaglandin E2 production as well as inducible nitric oxide synthase, cyclooxygenase-2, and tumor necrosis factor-α mRNA expression in response to lipopolysaccharide stimulation. Moreover, the hexane fraction from P. vulgaris var. lilacina significantly inhibited the activation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and the nuclear translocation of the NF-κB p50 and p65 subunits. These results indicate that P. vulgaris var. lilacina has an anti-inflammatory capacity in vitro, suggesting that it could be a potential source of natural anti-inflammatory agents. View Full-Text
Keywords: Prunella vulgaris var. lilacina; anti-inflammation; NO; PGE2; NF-κB Prunella vulgaris var. lilacina; anti-inflammation; NO; PGE2; NF-κB
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MDPI and ACS Style

Hwang, Y.-J.; Lee, E.-J.; Kim, H.-R.; Hwang, K.-A. NF-κB-Targeted Anti-Inflammatory Activity of Prunella vulgaris var. lilacina in Macrophages RAW 264.7. Int. J. Mol. Sci. 2013, 14, 21489-21503. https://doi.org/10.3390/ijms141121489

AMA Style

Hwang Y-J, Lee E-J, Kim H-R, Hwang K-A. NF-κB-Targeted Anti-Inflammatory Activity of Prunella vulgaris var. lilacina in Macrophages RAW 264.7. International Journal of Molecular Sciences. 2013; 14(11):21489-21503. https://doi.org/10.3390/ijms141121489

Chicago/Turabian Style

Hwang, Yu-Jin, Eun-Ju Lee, Haeng-Ran Kim, and Kyung-A Hwang. 2013. "NF-κB-Targeted Anti-Inflammatory Activity of Prunella vulgaris var. lilacina in Macrophages RAW 264.7" International Journal of Molecular Sciences 14, no. 11: 21489-21503. https://doi.org/10.3390/ijms141121489

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